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Details on Person Expression of Preprolactin
Class:Id BlackBoxEvent:934641
_displayName Expression of Preprolactin
_timestamp 2018-10-31 14:31:14
authored [InstanceEdit:933748] May, B, 2010-08-16
compartment [Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created [InstanceEdit:934645] May, B, 2010-08-17
edited [InstanceEdit:933748] May, B, 2010-08-16
isChimeric FALSE
literatureReference [LiteratureReference:934642] Molecular cloning and nucleotide sequence of DNA complementary to human decidual prolactin mRNA [LiteratureReference:935985] Human prolactin gene promoter regulation by estrogen: convergence with tumor necrosis factor-alpha signaling
modified [InstanceEdit:934667] May, B, 2010-08-17 [InstanceEdit:935992] May, B, 2010-08-18 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9627000] May, Bruce, 2018-10-31 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04
name Expression of Preprolactin
output [EntityWithAccessionedSequence:445289] PRL(1-227) [cytosol] [Homo sapiens]
regulatedBy [PositiveGeneExpressionRegulation:935982] Positive gene expression regulation by 'EST17b [cytosol]' [PositiveGeneExpressionRegulation:935988] Positive gene expression regulation by 'TNF(1-233) [plasma membrane]' [NegativeGeneExpressionRegulation:935991] Negative gene expression regulation by 'DA [extracellular region]'
regulationReference [RegulationReference:9641688] Positive gene expression regulation by 'TNF(1-233) [plasma membrane]' Human prolactin gene promoter regulation by estrogen: convergence with tumor necrosis factor-alpha signaling [RegulationReference:9642269] Positive gene expression regulation by 'EST17b [cytosol]' Human prolactin gene promoter regulation by estrogen: convergence with tumor necrosis factor-alpha signaling [RegulationReference:9642614] Negative gene expression regulation by 'DA [extracellular region]' Inhibitory control of prolactin and Pit-1 gene promoters by dopamine. Dual signaling pathways required for D2 receptor-regulated expression of the prolactin gene
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:8921001] R-HSA-934641.1
summation [Summation:934644] The preprolactin gene is transcribed to yield mRNA and the m... [Summation:935987] As inferred from rat, dopamine inhibits transcription of the...
(hasEvent) [Pathway:933744] Synthesis and Secretion of Prolactin [Homo sapiens]
(precedingEvent) [Reaction:445292] Signal Recognition (Preprolactin) [Homo sapiens]
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No pathways have been reviewed or authored by Expression of Preprolactin (934641)