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Details on Person Phosphorylated SPRY2 is ubiquitinated by CBL

Class:Id	Reaction:934604
_displayName	Phosphorylated SPRY2 is ubiquitinated by CBL
_doRelease	TRUE
_timestamp	2024-02-17 18:22:00
authored	[InstanceEdit:934560] Williams, MG, 2010-08-17
catalystActivity	[CatalystActivity:934571] ubiquitin protein ligase activity of Y55/Y227-pSPRY2:CBL [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:934557] Williams, MG, 2010-08-17
figure	[Figure:947937] /figures/DrosRasRafERKA103.jpg
input	[Complex:934576] Y55/Y227-pSPRY2:CBL [plasma membrane] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:188630] Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops [LiteratureReference:183004] hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl
modified	[InstanceEdit:947760] Williams, MG, 2010-09-13 [InstanceEdit:947989] Williams, MG, 2010-09-14 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1295635] Rothfels, K, 2011-05-17 [InstanceEdit:1498851] Rothfels, K, 2011-08-18 [InstanceEdit:1549614] Rothfels, K, 2011-08-30 [InstanceEdit:1580759] Rothfels, K, 2011-09-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9861373] D'Eustachio, Peter, 2024-02-17
name	Phosphorylated SPRY2 is ubiquitinated by CBL
output	[Complex:934572] Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1295622] SPRY2 binds CBL [Homo sapiens] [Reaction:1295609] SRC phosphorylates SPRY2 on Y55 and Y227 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591357] R-HSA-934604.3
summation	[Summation:934616] In humans, the phosphorylated adaptor protein Sprouty2 is ub...
(hasEvent)	[Pathway:481001] Ras/Raf/ERK pathway - Inferred Events [Pathway:1295596] Spry regulation of FGF signaling [Homo sapiens]
(inferredFrom)	[Reaction:934606] Phosphorylated STY is ubiquitinated by CBL [Drosophila melanogaster]
(precedingEvent)	[Reaction:1295621] CBL dissociates from ubiquitinated p-SPRY2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9864228] Update Tracker - [Reaction:934604] Phosphorylated SPRY2 is ubiquitinated by CBL - v88:[removeLiteratureReference]
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