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Details on Person SPRY2 is phosphorylated by phosphorylated MNK1

Class:Id	Reaction:934559
_displayName	SPRY2 is phosphorylated by phosphorylated MNK1
_doRelease	TRUE
_timestamp	2011-09-09 08:57:18
authored	[InstanceEdit:934560] Williams, MG, 2010-08-17
catalystActivity	[CatalystActivity:934611] protein serine/threonine kinase activity of p-T250,T255,T385,S437-MKNK1 [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:934557] Williams, MG, 2010-08-17
figure	[Figure:947987] /figures/DrosRasRafERKA90.jpg
input	[Complex:934550] PP2A(A:C):SPRY2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:188721] Regulation of sprouty stability by Mnk1-dependent phosphorylation [LiteratureReference:934614] Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation
modified	[InstanceEdit:947865] Williams, MG, 2010-09-14 [InstanceEdit:947989] Williams, MG, 2010-09-14 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1498861] Rothfels, K, 2011-08-18 [InstanceEdit:1549610] Rothfels, K, 2011-08-30 [InstanceEdit:1580772] Rothfels, K, 2011-09-07 [InstanceEdit:1583720] Rothfels, K, 2011-09-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SPRY2 is phosphorylated by phosphorylated MNK1
output	[Complex:934578] PP2A(A:C):S112/S121-pSPRY2 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1295599] SPRY2 translocates to the plasma membrane [Homo sapiens] [Reaction:1295632] PPA2A dephosphorylates SPRY2 [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591279] R-HSA-934559.2
summation	[Summation:934591] In humans, the phosphorylated MNK1 kinase phosphorylates the...
(hasEvent)	[Pathway:481001] Ras/Raf/ERK pathway - Inferred Events [Pathway:1295596] Spry regulation of FGF signaling [Homo sapiens]
(inferredFrom)	[Reaction:934556] STY is phosphorylated by phosphorylated LK6 [Drosophila melanogaster]
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No pathways have been reviewed or authored by SPRY2 is phosphorylated by phosphorylated MNK1 (934559)