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Details on Person UniProt:Q27977 ITGA5
| Class:Id | ReferenceGeneProduct:93433 |
|---|---|
| _chainChangeLog | chain:- added on Sat February 7 2015;chain:-252 added on Sat February 7 2015;chain:253- added on Sat February 7 2015;chain:1-385 for 93433 removed on Fri August 11 2023;chain:1-252 for 93433 removed on Fri August 11 2023;chain:253-385 for 93433 removed on Fri August 11 2023;chain:1-1164 for 93433 added on Fri August 11 2023;signal peptide:1- for 93433 added on Fri August 11 2023;chain:-1009 for 93433 added on Fri August 11 2023;chain:1010-1164 for 93433 added on Fri August 11 2023 |
| _displayName | UniProt:Q27977 ITGA5 |
| _timestamp | 2025-02-21 20:10:31 |
| chain | chain:1-1164 signal peptide:1- chain:-1009 chain:1010-1164 |
| checksum | 2E8AD8D0EFE4E45F |
| comment | FUNCTION Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity).SUBUNIT Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with NISCH. Interacts with HPS5. Interacts with RAB21 and COMP. Interacts with CIB1. ITGA5:ITGB1 interacts with CCN3. ITGA5:ITGB1 interacts with FBN1. ITGA5:ITGB1 interacts with IL1B. ITGA5:ITGB1 interacts with ACE2. ITGA5:ITGB1 interacts with SELP (By similarity). Interacts with ANGPT2. ITGA5:ITGB1 interacts with IGFBP2 (By similarity). ITGA5:ITGB1 interacts with IGFBP1 (By similarity).SUBCELLULAR LOCATION Proteolytic cleavage by PCSK5 mediates activation of the precursor.SIMILARITY Belongs to the integrin alpha chain family. |
| description | recommendedName: Integrin alpha-5 alternativeName: Fibronectin receptor subunit alpha alternativeName: Integrin alpha-F alternativeName: VLA-5 component recommendedName: Integrin alpha-5 heavy chain /component component recommendedName: Integrin alpha-5 light chain /component |
| geneName | ITGA5 |
| identifier | Q27977 |
| isSequenceChanged | FALSE |
| keyword | Calcium Cell adhesion Cell junction Cell membrane Cleavage on pair of basic residues Disulfide bond Glycoprotein Integrin Membrane Metal-binding Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | ITGA5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ITA5_BOVIN F1MK44 |
| sequenceLength | 1164 |
| species | [Species:48898] Bos taurus |
| (referenceEntity) | [EntityWithAccessionedSequence:9865214] ITGA5 [plasma membrane] [Bos taurus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q27977 ITGA5 (93433)
