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Details on Person UniProt:Q9XTN2 chico
| Class:Id | ReferenceGeneProduct:93397 |
|---|---|
| _chainChangeLog | chain:1-968 added on Fri February 6 2015 |
| _displayName | UniProt:Q9XTN2 chico |
| _timestamp | 2026-02-20 22:11:19 |
| chain | chain:1-968 |
| checksum | 04E9856F37F7A4CF |
| comment | FUNCTION Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity). May mediate the control of various cellular processes by insulin-like peptides. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains. Involved in control of cell proliferation, cell size, and body and organ growth throughout development. Also has a role in a signaling pathway controlling the physiological response required to endure periods of low nutrient conditions. Insulin/insulin-like growth factor (IGF) signaling pathway has a role in regulating aging and is necessary in the ovary for vitellogenic maturation.SUBUNIT Bindings to phosphatidylinositol 3-kinase and SHP2.DEVELOPMENTAL STAGE Expressed during G1, S and G2 phase of the cell cycle.DISRUPTION PHENOTYPE Female sterile. Extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes.MISCELLANEOUS 'Chico' means 'small boy' in Spanish.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Insulin receptor substrate 1 shortName: dIRS alternativeName: Protein chico |
| geneName | chico IRS CG5686 |
| identifier | Q9XTN2 |
| isSequenceChanged | FALSE |
| keyword | Differentiation Growth regulation Oogenesis Phosphoprotein Reference proteome Repeat |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | chico |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | IRS1_DROME D0UY43 D0UY45 D0UY46 D0UY47 D0UY49 D0UY50 D0UY51 D0UY52 D0UY54 D0UY55 D0UY61 D0UY62 D0UY64 D0UY65 D0UY66 D0UY67 D0UY68 Q5U0V5 Q9U4G2 |
| sequenceLength | 968 |
| species | [Species:56210] Drosophila melanogaster |
| (referenceEntity) | [EntityWithAccessionedSequence:110429] CHICO [cytosol] [Drosophila melanogaster] [EntityWithAccessionedSequence:164698] Phospho CHICO [cytosol] [Drosophila melanogaster] |
| (referenceSequence) | [ModifiedResidue:164733] O4'-phospho-L-tyrosine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q9XTN2 chico (93397)
