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Details on Person Dimerization of p-IRF7

Class:Id	Reaction:933533
_displayName	Dimerization of p-IRF7
_doRelease	TRUE
_timestamp	2010-12-02 14:39:44
authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:933535] Garapati, P V, 2010-08-16
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
input	[EntityWithAccessionedSequence:450318] p-S477,S479-IRF7 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:450318] p-S477,S479-IRF7 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:933500] Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain [LiteratureReference:933439] Structural insights into interferon regulatory factor activation
modified	[InstanceEdit:975193] Shamovsky, V, 2010-09-22 [InstanceEdit:990524] Garapati, P V, 2010-11-03 [InstanceEdit:994081] Garapati, P V, 2010-11-05 [InstanceEdit:998145] Garapati, P V, 2010-11-09 [InstanceEdit:1022090] Garapati, P V, 2010-11-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dimerization of p-IRF7
output	[Complex:450344] p-2S-IRF7:p-2S-IRF7 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:933525] Phosphorylation and release of IRF7 [Homo sapiens] [Reaction:933538] Recruitment of IRF7 to TRAF6 [Homo sapiens] [Reaction:975106] Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation [Homo sapiens] [Reaction:975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105514] R-HSA-933533.2
summation	[Summation:933444] Phosphorylation stimulates the C-terminal autoinhibitory dom...
(hasEvent)	[Pathway:933541] TRAF6 mediated IRF7 activation [Homo sapiens] [Pathway:975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling [Homo sapiens]
(precedingEvent)	[Reaction:933531] Translocation of p-IRF7:p-IRF7 to nucleus [Homo sapiens] [Reaction:9604487] p-IRF7:p-IRF7 translocates to the nucleus [Homo sapiens]
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No pathways have been reviewed or authored by Dimerization of p-IRF7 (933533)