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Details on Person Processing of caspases

Class:Id	Reaction:933532
_displayName	Processing of caspases
_doRelease	TRUE
_timestamp	2023-05-18 14:10:13
authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
catalystActivity	[CatalystActivity:992767] cysteine-type endopeptidase activity of viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane]
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:933535] Garapati, P V, 2010-08-16
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
input	[Complex:933483] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-479), CASP10(1-521) [mitochondrial outer membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:141306] Caspase-10 is an initiator caspase in death receptor signaling [LiteratureReference:933437] Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases [LiteratureReference:933435] Caspases leave the beaten track: caspase-mediated activation of NF-kappaB [LiteratureReference:933511] Non-apoptotic functions of caspase-8 [LiteratureReference:933506] Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA
modified	[InstanceEdit:990524] Garapati, P V, 2010-11-03 [InstanceEdit:992766] Garapati, P V, 2010-11-04 [InstanceEdit:994081] Garapati, P V, 2010-11-05 [InstanceEdit:998145] Garapati, P V, 2010-11-09 [InstanceEdit:1022090] Garapati, P V, 2010-11-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8983918] Jupe, Steve, 2017-03-31 [InstanceEdit:9014715] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9835843] Shamovsky, Veronica, 2023-05-18
name	Processing of caspases
output	[Complex:8983916] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:RIPK1:FADD:2xCASP8(1-216), CASP10(1-219) [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:933460] CASP8(375-384) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:933460] CASP8(375-384) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:76158] CASP8(385-479) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:76158] CASP8(385-479) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:75975] CASP8(217-374) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:75975] CASP8(217-374) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:933458] CASP10(220-415) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:933455] CASP10(416-521) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:933455] CASP10(416-521) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:933458] CASP10(220-415) [cytosol] [Homo sapiens]
precedingEvent	[Reaction:933523] Dimerzation of procaspase-8, procaspase-10 [Homo sapiens] [Reaction:933526] Recruitment of caspase-8 and -10 to FADD complex [Homo sapiens] [BlackBoxEvent:6798139] TP53 stimulates CASP10 expression [Homo sapiens]
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104381] R-HSA-933532.5
summation	[Summation:933419] Processing of caspases is required for activation of downstr...
(hasEvent)	[Pathway:933543] NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 [Homo sapiens]
(precedingEvent)	[Reaction:933539] Recruitment of IKK complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781018] Update Tracker - [Reaction:933532] Processing of caspases - v61:[add_removeOutput]
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No pathways have been reviewed or authored by Processing of caspases (933532)