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Details on Person Activation of IKK by MEKK1

Class:Id	Reaction:933530
_displayName	Activation of IKK by MEKK1
_doRelease	TRUE
_timestamp	2023-05-18 15:18:31
authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
catalystActivity	[CatalystActivity:933529] MAP kinase kinase kinase activity of dsRNA:DDX58/IFIH1:MAVS:TRAF2/TRAF6:MEKK1 [mitochondrial outer membrane]
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:933535] Garapati, P V, 2010-08-16
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:168113] CHUK:IKBKB:IKBKG [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:165931] MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta [LiteratureReference:933487] Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway [LiteratureReference:434149] The nemo binding domains of both IKKalpha and IKKbeta regulate IKK complex assembly and classical NFkappaB activation [LiteratureReference:434140] IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program
modified	[InstanceEdit:990524] Garapati, P V, 2010-11-03 [InstanceEdit:994075] Garapati, P V, 2010-11-05 [InstanceEdit:998145] Garapati, P V, 2010-11-09 [InstanceEdit:1022090] Garapati, P V, 2010-11-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9835861] Shamovsky, Veronica, 2023-05-18
name	Activation of IKK by MEKK1
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:177663] IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] [Homo sapiens]
precedingEvent	[Reaction:933528] Interaction of MEKK1 with TRAF6 [Homo sapiens] [Reaction:918230] Recruitment of TRAF6/TRAF2 to MAVS [Homo sapiens]
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104129] R-HSA-933530.2
summation	[Summation:933443] In Human, IKKs - IkB kinase (IKK) complex serves as the mast...
(hasEvent)	[Pathway:933542] TRAF6 mediated NF-kB activation [Homo sapiens]
(inferredFrom)	[Reaction:1227783] Phosphorylation of IKKs complex mediated by MEKK1 [Gallus gallus]
(precedingEvent)	[Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789605] Update Tracker - [Reaction:933530] Activation of IKK by MEKK1 - v37:[modifyText]
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No pathways have been reviewed or authored by Activation of IKK by MEKK1 (933530)