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Details on Person Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
| Class:Id | LiteratureReference:933491 |
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| _displayName | Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 |
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| _timestamp | 2010-08-16 14:56:49 |
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| author | [Person:434072] Kawai, T
[Person:165851] Sato, S
[Person:177883] Ishii, KJ
[Person:177859] Coban, C
[Person:165858] Hemmi, H
[Person:75497] Yamamoto, M
[Person:416767] Terai, K
[Person:111021] Matsuda, M
[Person:169935] Inoue, J
[Person:165859] Uematsu, S
[Person:165855] Takeuchi, O
[Person:168004] Akira, Shizuo |
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| created | [InstanceEdit:933505] Garapati, P V, 2010-08-16 |
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| journal | Nat Immunol |
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| pages | 1061-8 |
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| pubMedIdentifier | 15361868 |
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| title | Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 |
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| volume | 5 |
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| year | 2004 |
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| (literatureReference) | [Complex:975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] [Homo sapiens]
[Complex:975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] [Homo sapiens]
[Reaction:933538] Recruitment of IRF7 to TRAF6 [Homo sapiens]
[BlackBoxEvent:975118] TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex [Homo sapiens]
[Reaction:975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9 [Homo sapiens]
[Reaction:975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation [Homo sapiens]
[Summation:975096] TRAF6 E3 ubiquitin ligase activity was shown to be essential...
[Summation:975120] Upon TLR7/8 or 9 stimulation IRF7, but not IRF3, forms a sig...
[Summation:975136] In plasmacytoid dendritic cell induction of type I IFNs crit...
[CatalystActivityReference:9643751] ubiquitin-protein transferase activity of IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 |
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