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Details on Person UniProt:P09208 InR
| Class:Id | ReferenceGeneProduct:93261 |
|---|---|
| _chainChangeLog | signal peptide:1- added on Fri February 6 2015;chain:651-1081 added on Fri February 6 2015;chain:1086-2144 added on Fri February 6 2015;chain:1086- added on Fri February 6 2015;chain:-2144 added on Fri February 6 2015;signal peptide:1- for 93261 removed on Mon Feb 26 2024;chain:651-1081 for 93261 removed on Mon Feb 26 2024;signal peptide:1-43 for 93261 added on Mon Feb 26 2024;chain:-1081 for 93261 added on Mon Feb 26 2024 |
| _displayName | UniProt:P09208 InR |
| _timestamp | 2025-02-21 18:37:35 |
| chain | signal peptide:1-43 chain:-1081 chain:1086-2144 chain:1086- chain:-2144 |
| checksum | C4A8ECB08C70523A |
| comment | FUNCTION Has a ligand-stimulated tyrosine-protein kinase activity (PubMed:7628438, PubMed:8603594). Binds 3 insulin-like peptide ligands (PubMed:37805602). Regulates cell number and cell size during development by regulating cell growth and survival, affecting body size and organ size, including ovaries and imaginal disks (PubMed:10455177, PubMed:11250149, PubMed:8603594). Plays a role in life-span determination (PubMed:11292875). May be involved in regulation of other neuroendocrine signaling pathways (PubMed:11292875). Involved in the development of the embryonic nervous system (PubMed:7628438). Functions upstream of dock/dreadlocks for photoreceptor (R cell) axon guidance and targeting in the visual system (PubMed:12702880). Involved in the acs mediated recovery of gut enterocytes following the cytoplasmic purge response to intestinal bacterial infection (PubMed:37636057).CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)COFACTOR Activated in response to insulin (PubMed:11292875, PubMed:7628438, PubMed:8603594). Autophosphorylation activates the kinase activity.SUBUNIT Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds (PubMed:37805602). The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain (By similarity). Interacts (via C-terminal cytoplasmic region) with dock/dreadlocks (via SH2 and SH3 domains); when autophosphorylated (PubMed:12702880). May interact (via beta subunit) with chico/IRS-1; this interaction may lead to tyrosine phosphorylation of the insulin receptor substrate chico (PubMed:10455177). Interacts with Elp6; the interaction may stabilize Elp6 (PubMed:22645656).INTERACTION Enriched in the axons and growth cones of R cells.DEVELOPMENTAL STAGE Abundantly and widely expressed throughout embryogenesis with peak expression between 8 and 12 hours after egg laying (PubMed:2454394, PubMed:3014506, PubMed:7628438). By stages 9-11 enriched in all three germ layers, including in the posterior midgut primordium, epidermis and neuroblasts with lower levels in the mesoderm (PubMed:7628438). By stage 12 highly expressed throughout the epidermis, in the migrating midgut primordia, hindgut and in the developing ventral cord (PubMed:7628438). By stage 16 expression in the epidermis and gut declines but persists in ventral cord and developing brain (PubMed:2454394, PubMed:7628438). In larvae expression is limited to nervous system and imaginal disks (PubMed:2454394). In third-instar larvae, protein is ubiquitously present but enriched in photoreceptor cells (R cells) of the eye-brain complex (PubMed:12702880). Expressed at high levels in the adult nervous system and ovaries (PubMed:2454394).PTM The 280 kDa proreceptor is proteolytically processed to form a 120 kDa alpha subunit and a 170 kDa beta subunit. The beta subunit undergoes cell-specific cleavage to generate a 90 kDa beta subunit and a free 60 kDa C-terminal subunit. Both the 90 kDa and the 170 kDa beta subunits can assemble with the alpha subunits to form mature receptors.PTM Autophosphorylated on tyrosine residues, including Tyr-1549 and Tyr-1550, in response to exogenous insulin (PubMed:12702880, PubMed:18327897, PubMed:21707536, PubMed:3014506). Tyr-1549 and Tyr-1550 are dephosphorylated by Ptp61F recruited by the dock/dreadlocks adapter protein (PubMed:21707536).PTM Phosphorylation of Tyr-1354 is required for Chico-binding.DISRUPTION PHENOTYPE Embryonic lethal (PubMed:7628438). A small number of individuals survive to late larval stage with a phenotype resembling Elp6 mutants, spending twice as long in third instar stage, and developing melanotic masses in the hemolymph (PubMed:22645656). RNAi-mediated knockdown in gut enterocytes impairs recovery of intestinal wall thickness after the cytoplasmic purge response to intestinal bacterial infection (PubMed:37636057).SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. |
| description | recommendedName: Insulin-like receptor shortName evidence="25"dIR shortName evidence="24"dInr shortName evidence="23"dmIR ecNumber evidence="7 22"2.7.10.1 alternativeName: Insulin receptor homolog shortName: dIRH alternativeName: fullName evidence="7"Receptor protein-tyrosine kinase InR component recommendedName: Insulin-like receptor subunit alpha /component component recommendedName: Insulin-like receptor subunit beta 1 alternativeName: fullName evidence="26"Insulin-like receptor subunit beta 170 kDa form shortName evidence="24"beta170 /component component recommendedName: Insulin-like receptor subunit beta 2 alternativeName: fullName evidence="26"Insulin-like receptor subunit beta 90 kDa form shortName evidence="24"beta90 /component component recommendedName: fullName evidence="26"60 kDa C-terminal fragment alternativeName: fullName evidence="24"Insulin-like receptor free C-terminus /component |
| geneName | InR Dir-a Inr-a IR CG18402 |
| identifier | P09208 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cell membrane Cell projection Cleavage on pair of basic residues Developmental protein Differentiation Disulfide bond Glycoprotein Growth regulation Kinase Manganese Membrane Metal-binding Neurogenesis Nucleotide-binding Phosphoprotein Receptor Reference proteome Repeat SH3-binding Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | InR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | INSR_DROME B7Z0N6 Q24023 Q24089 Q9VD94 |
| sequenceLength | 2144 |
| species | [Species:56210] Drosophila melanogaster |
| (referenceEntity) | [EntityWithAccessionedSequence:110420] INR alpha subunit [plasma membrane] [Drosophila melanogaster] [EntityWithAccessionedSequence:110421] INR beta subunit [plasma membrane] [Drosophila melanogaster] [EntityWithAccessionedSequence:110423] phospho-insulin receptor beta subunit [plasma membrane] [Drosophila melanogaster] [EntityWithAccessionedSequence:377089] Phospho INR beta subunit [plasma membrane] [Drosophila melanogaster] |
| (referenceSequence) | [ModifiedResidue:164878] O4'-phospho-L-tyrosine at unknown position |
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No pathways have been reviewed or authored by UniProt:P09208 InR (93261)
