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Details on Person UniProt:P52293 Kpna2
| Class:Id | ReferenceGeneProduct:93156 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-529 added on Fri February 6 2015;initiator methionine:1 for 93156 removed on Fri Nov 03 2023;initiator methionine: for 93156 added on Fri Nov 03 2023;initiator methionine: for 93156 removed on Fri Aug 15 2025;initiator methionine:1 for 93156 added on Fri Aug 15 2025 |
| _displayName | UniProt:P52293 Kpna2 |
| _timestamp | 2025-08-15 21:00:25 |
| chain | initiator methionine:1 chain:2-529 |
| checksum | 19E64AA3E9C3C7B5 |
| comment | FUNCTION Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:21690087). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:21690087). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (By similarity).SUBUNIT Heterodimer; with KPNB1 (By similarity). Component of a complex containing CSE1L, RAN and KPNA2 (By similarity). Interacts directly with CSE1L (By similarity). Interacts with PLAG1 (By similarity). Interacts with APEX1 (via N-terminus) (By similarity). Interacts with FRG1 (via N-terminus) (By similarity). Interacts with ARL4A, CTNNBL1 and NBN (By similarity). Interacts with ANP32E (PubMed:10692581). Interacts with SNAI1 (via zinc fingers) (PubMed:21454664). Interacts with SNAI2 (via zinc fingers) (By similarity). Interacts with BAG6 (By similarity). Interacts with AIFM2; this interaction likely mediates the translocation of AIFM2 into the nucleus upon oxidative stress. Interacts with RSL1D1 (By similarity). Interacts with BAP1 (via C-terminus); the interaction contributes to BAP1 nuclear localization (By similarity). Interacts with PLSCR4; this interaction mediates the nucleus import of PLSCR4 (By similarity).INTERACTION Slightly detected in brain but not in cerebellum and skeletal muscle, highly expressed in testis and spleen.DOMAIN Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.DOMAIN The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins.DOMAIN The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding.PTM Ubiquitinated. Deubiquitinated by USP22; leading to stabilization and increased activity.SIMILARITY Belongs to the importin alpha family. |
| description | recommendedName: fullName evidence="10"Importin subunit alpha-1 alternativeName: Importin alpha P1 alternativeName: Karyopherin subunit alpha-2 alternativeName: Pendulin alternativeName: Pore targeting complex 58 kDa subunit shortName: PTAC58 alternativeName: RAG cohort protein 1 alternativeName: SRP1-alpha |
| geneName | Kpna2 Rch1 |
| identifier | P52293 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cytoplasm Nucleus Phosphoprotein Protein transport Reference proteome Repeat Transport Ubl conjugation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Kpna2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | IMA1_MOUSE Q64292 |
| sequenceLength | 529 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9619124] Kpna2 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9619128] Kpna2 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P52293 Kpna2 (93156)
