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Details on Person UniProt:P48598 eIF4E1
| Class:Id | ReferenceGeneProduct:92924 |
|---|---|
| _chainChangeLog | chain:1-259 added on Sat February 7 2015 |
| _displayName | UniProt:P48598 eIF4E1 |
| _timestamp | 2024-08-09 19:02:05 |
| chain | chain:1-259 |
| checksum | B844B2DD5738758E |
| comment | FUNCTION Recognizes and binds the 7-methylguanosine (m7G)-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:8663200). In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and down-regulates their expression during the maternal-to-zygotic transition (PubMed:28875934).SUBUNIT eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E1 and eIF4G1 (PubMed:25702871). Recruited by cup in oocytes and in early embryos, preventing the interaction with eIF4G (PubMed:14685270, PubMed:14691132, PubMed:14723848, PubMed:22832024, PubMed:26294658). The interaction with cup therefore prevents the translation of key transcripts such as oskar (osk) and nanos (nos) in some regions in the early embryo (PubMed:14685270, PubMed:14691132, PubMed:14723848, PubMed:22832024, PubMed:26294658). Interacts with mxt (PubMed:23716590, PubMed:26294658). Interacts with 4E-T and Thor (PubMed:11389445, PubMed:14645523, PubMed:25702871, PubMed:26294658). Forms a RNP containing at least me31B, eIF4E1, cup, tral and pAbp; this interaction is required for the translational silencing of maternal mRNAs during the maternal-to-zygotic transition (PubMed:28875934).INTERACTION Expressed at the posterior end of developing oocytes (at protein level) (PubMed:20869429). Preferential expression in the pole cells, at different developmental stages (PubMed:9065696).DEVELOPMENTAL STAGE High levels of expression in early embryos, with levels decreasing slightly over the first 5 hours of embryogenesis (at protein level) (PubMed:28875934). Throughout development (PubMed:7742371, PubMed:9065696).PTM Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.SIMILARITY Belongs to the eukaryotic initiation factor 4E family. |
| description | recommendedName: Eukaryotic translation initiation factor 4E1 alternativeName: eIF-4F 25 kDa subunit alternativeName: fullName evidence="22"mRNA cap-binding protein |
| geneName | eIF4E1 eIF-4E Eif4e CG4035 |
| identifier | P48598 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Initiation factor Nucleus Phosphoprotein Protein biosynthesis Reference proteome RNA-binding Translation regulation |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9607352] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9706439] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | eIF4E1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | IF4E_DROME A4V1Q6 Q95SV3 Q9VSX8 Q9VSX9 |
| sequenceLength | 259 |
| species | [Species:56210] Drosophila melanogaster |
| (isoformParent) | [ReferenceIsoform:148717] UniProt:P48598-2 eIF4E1 [Drosophila melanogaster] [ReferenceIsoform:404144] UniProt:P48598-1 eIF4E1 [Drosophila melanogaster] |
| (referenceEntity) | [EntityWithAccessionedSequence:110511] EIF-4E [cytosol] [Drosophila melanogaster] |
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No pathways have been reviewed or authored by UniProt:P48598 eIF4E1 (92924)
