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Details on Person UniProt:Q9JHJ8 Icoslg
| Class:Id | ReferenceGeneProduct:92812 |
|---|---|
| _chainChangeLog | signal peptide:1-46 added on Sat February 7 2015;chain:47-322 added on Sat February 7 2015;signal peptide:1-46 for 92812 removed on Sun Nov 03 2024;chain:47-322 for 92812 removed on Sun Nov 03 2024;signal peptide:1-43 for 92812 added on Sun Nov 03 2024;chain:44-322 for 92812 added on Sun Nov 03 2024 |
| _displayName | UniProt:Q9JHJ8 Icoslg |
| _timestamp | 2025-05-21 21:12:23 |
| chain | signal peptide:1-43 chain:44-322 |
| checksum | 55CCBA4AD12E47E6 |
| comment | FUNCTION Ligand for the T-cell-specific cell surface receptor ICOS (PubMed:10549624, PubMed:10617205, PubMed:10657606). Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; also induces B-cell proliferation and differentiation into plasma cells (PubMed:10549624, PubMed:10617205, PubMed:10657606). Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (Probable). During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype.SUBUNIT Interacts with CTLA4 (in vitro) (By similarity). The interaction with CTLA4 is not observed in different experimental settings (PubMed:10549624).SUBCELLULAR LOCATION Expressed in lymphoid tissues, primarily in B-cell areas (PubMed:10617205, PubMed:10657606). In the lymph nodes, strongly expressed in the cortex and in both primary and secondary follicles. In other lymphoid tissues, primarily found in the marginal zone of the spleen, the follicles in the Peyer's patches and the medulla of the thymus (PubMed:10549624, PubMed:10617205). Detected on resting splenic T-cells (at protein level) (PubMed:10549624, PubMed:10657606). Also expressed in nonlymphoid tissues, such as lung and thymus, as well as, at very low levels, in kidney, liver, peritoneum and testis (PubMed:10549624).TISSUE SPECIFICITY Expressed in brain, heart, spleen, lung, liver skeletal muscle, kidney and testis.TISSUE SPECIFICITY Expressed in heart, spleen and kidney.DEVELOPMENTAL STAGE Detected early in hemopoiesis: in the yolk sac at 11.5 and 12.5 dpc and, to a lesser extent, in the liver at 14.5 dpc.INDUCTION Up-regulated by TNF and LPS in nonlymphoid tissues.SIMILARITY Belongs to the immunoglobulin superfamily. BTN/MOG family. |
| description | recommendedName: ICOS ligand alternativeName: B7 homolog 2 shortName: B7-H2 alternativeName: fullName evidence="10"B7-like protein Gl50 alternativeName: fullName evidence="9"B7-related protein 1 shortName evidence="9"B7RP-1 alternativeName: LICOS cdAntigenNameCD275/cdAntigenName |
| geneName | Icoslg B7h B7h2 B7rp1 Icosl |
| identifier | Q9JHJ8 |
| isSequenceChanged | FALSE |
| keyword | Adaptive immunity Alternative splicing B-cell activation Cell membrane Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane Reference proteome Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | Icoslg |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ICOSL_MOUSE |
| sequenceLength | 322 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:148689] UniProt:Q9JHJ8-2 Icoslg [Mus musculus] [ReferenceIsoform:414481] UniProt:Q9JHJ8-1 Icoslg [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9966423] Icoslg [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q9JHJ8 Icoslg (92812)
