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Details on Person mRNA Cleaved by SMG6 [cytosol]

Class:Id	Complex:927845
_displayName	mRNA Cleaved by SMG6 [cytosol]
_timestamp	2011-06-10 08:59:55
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:927892] May, B, 2010-08-10
hasComponent	[Complex:162460] Cap Binding Complex (CBC) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:162458] NCBP2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:162459] NCBP1 [cytosol] [Homo sapiens] [Complex:377182] PP2A (Aalpha:B55alpha:Calpha) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:165982] PPP2R1A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:377253] PPP2R2A [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:165971] PPP2CA [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:156803] PABPC1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:927851] SMG6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:927856] p-4S-UPF1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] [Homo sapiens] [OtherEntity:927738] 3' Fragment of Cleaved mRNA [cytosol] [OtherEntity:927835] 5' Fragment of Cleaved mRNA [cytosol] [EntityWithAccessionedSequence:927867] SMG5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:927838] SMG7 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1295741] SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay
modified	[InstanceEdit:1295752] May, B, 2011-05-18
name	mRNA Cleaved by SMG6
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1358005] R-HSA-927845.1
(input)	[BlackBoxEvent:927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex [Homo sapiens]
(output)	[BlackBoxEvent:927836] SMG6 hydrolyzes mRNA with premature termination codon [Homo sapiens]
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No pathways have been reviewed or authored by mRNA Cleaved by SMG6 [cytosol] (927845)