Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person SMG6 hydrolyzes mRNA with premature termination codon

Class:Id	BlackBoxEvent:927836
_displayName	SMG6 hydrolyzes mRNA with premature termination codon
_doRelease	TRUE
_timestamp	2014-02-05 02:42:07
authored	[InstanceEdit:927774] May, B, 2010-08-06
catalystActivity	[CatalystActivity:927876] RNA endonuclease activity of Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:927892] May, B, 2010-08-10
edited	[InstanceEdit:927774] May, B, 2010-08-06
input	[Complex:927854] Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:927887] SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells [LiteratureReference:927882] Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex [LiteratureReference:927772] SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan
modified	[InstanceEdit:975960] May, B, 2010-10-11 [InstanceEdit:1010014] May, B, 2010-11-11 [InstanceEdit:1082222] May, B, 2010-11-29 [InstanceEdit:1216458] May, B, 2011-02-14 [InstanceEdit:1221618] May, B, 2011-02-25 [InstanceEdit:1295754] May, B, 2011-05-18 [InstanceEdit:1296157] May, B, 2011-05-19 [InstanceEdit:5251727] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SMG6 hydrolyzes mRNA with premature termination codon
output	[Complex:927845] mRNA Cleaved by SMG6 [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A [Homo sapiens] [Reaction:927889] SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) [Homo sapiens]
releaseDate	2011-06-14
reviewed	[InstanceEdit:1296158] Neu-Yilik, G, 2011-05-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1357519] R-HSA-927836.2
summation	[Summation:927884] SMG6 is an endoribonuclease which cleaves the mRNA bound by ...
(hasEvent)	[Pathway:975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by SMG6 hydrolyzes mRNA with premature termination codon (927836)