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Details on Person Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
Class:Id BlackBoxEvent:927830 _displayName Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex _doRelease TRUE _timestamp 2017-09-29 10:30:40 authored [InstanceEdit:927774] May, B, 2010-08-06 compartment [Compartment:70101] cytosol created [InstanceEdit:927892] May, B, 2010-08-10 edited [InstanceEdit:927774] May, B, 2010-08-06 input [Complex:927845] mRNA Cleaved by SMG6 [cytosol] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:927772] SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan [LiteratureReference:927887] SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells [LiteratureReference:927751] Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1 [LiteratureReference:927885] Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway [LiteratureReference:433068] Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay [LiteratureReference:927764] Premature termination codons enhance mRNA decapping in human cells [LiteratureReference:927847] Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities [LiteratureReference:429884] Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover [LiteratureReference:927768] SMG7 acts as a molecular link between mRNA surveillance and mRNA decay [LiteratureReference:927794] Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7 [LiteratureReference:1295746] Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay [LiteratureReference:1295741] SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay [LiteratureReference:975936] Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors [LiteratureReference:1295727] How and where are nonsense mRNAs degraded in mammalian cells? modified [InstanceEdit:975960] May, B, 2010-10-11 [InstanceEdit:1010014] May, B, 2010-11-11 [InstanceEdit:1014254] May, B, 2010-11-14 [InstanceEdit:1082222] May, B, 2010-11-29 [InstanceEdit:1216458] May, B, 2011-02-14 [InstanceEdit:1221618] May, B, 2011-02-25 [InstanceEdit:1295754] May, B, 2011-05-18 [InstanceEdit:1296157] May, B, 2011-05-19 [InstanceEdit:5251727] May, B, 2014-02-05 [InstanceEdit:9023978] May, Bruce, 2017-09-29 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex output [Complex:162460] Cap Binding Complex (CBC) [cytosol] [Homo sapiens] [Complex:377182] PP2A (Aalpha:B55alpha:Calpha) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:156803] PABPC1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:927851] SMG6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:927734] UPF1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:72584] EIF4G1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:927867] SMG5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:927838] SMG7 [cytosol] [Homo sapiens] precedingEvent
regulatedBy [Requirement:9023972] Requirement by 'p-4S-UPF1 [cytosol]' [Requirement:9023974] Requirement by 'PP2A (Aalpha:B55alpha:Calpha) [cytosol]' regulationReference [RegulationReference:9641710] Requirement by 'PP2A (Aalpha:B55alpha:Calpha) [cytosol]' Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7 [RegulationReference:9641904] Requirement by 'p-4S-UPF1 [cytosol]' Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay releaseDate 2011-06-14 reviewed [InstanceEdit:1296158] Neu-Yilik, G, 2011-05-19 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:1357526] R-HSA-927830.5 summation [Summation:927874] SMG6 endonucleolytically cleaves an mRNA it is believed that... (hasEvent) [Pathway:975957] Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) [Homo sapiens] (updatedInstance) [_UpdateTracker:9780481] Update Tracker - [BlackBoxEvent:927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex - v63:[addRegulator, removeCatalystActivity]
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