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Details on Person UniProt:P97378 Il12rb2
| Class:Id | ReferenceGeneProduct:92711 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-874 added on Fri February 6 2015 |
| _displayName | UniProt:P97378 Il12rb2 |
| _timestamp | 2024-08-09 19:21:45 |
| chain | signal peptide:1-23 chain:24-874 |
| checksum | 582E4D21BF1FBD67 |
| comment | FUNCTION Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Can also activate STAT3.SUBUNIT Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain (By similarity).INTERACTION Expressed in developing T-helper (TH) cells.DEVELOPMENTAL STAGE Expressed at high levels in Th1 cells on day 3, 5 and 7 after primary activation. Very low expression in Th2 cells on day 3 and not detectable on day 5 nor day 7 after activation.INDUCTION Following T-cell activation, expression inhibited by IL4 and induced by IFN gamma.DOMAIN The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.DOMAIN The box 1 motif is required for JAK interaction and/or activation.PTM On IL12 stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation of any one of Tyr-757, Tyr-804 or Tyr-811 can activate STAT4, IFN-gamma production, and T-cell proliferation. Tyr-811 is the dominant site of cell proliferation.MISCELLANEOUS Lps-defective mice C57BL/10ScCr (Cr) mice carry a mutation in the IL12RB2 gene leading to the production of a truncated IL12 receptor beta 2 chain resulting in malfunction of the IL12-mediated IFN-gamma response.SIMILARITY Belongs to the type I cytokine receptor family. Type 2 subfamily. |
| description | recommendedName: Interleukin-12 receptor subunit beta-2 shortName: IL-12 receptor subunit beta-2 shortName: IL-12R subunit beta-2 shortName: IL-12R-beta-2 shortName: IL-12RB2 |
| geneName | Il12rb2 |
| identifier | P97378 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Membrane Phosphoprotein Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Il12rb2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | I12R2_MOUSE B9EHD9 |
| sequenceLength | 874 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9006473] p-Y800-Il12rb2 [plasma membrane] [Mus musculus] [EntityWithAccessionedSequence:9943428] Il12rb2 [plasma membrane] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:9006463] O4'-phospho-L-tyrosine at 800 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P97378 Il12rb2 (92711)
