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Details on Person Diagram of Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
| Class:Id | PathwayDiagram:925713 |
|---|---|
| _displayName | Diagram of Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| _timestamp | 2024-03-28 00:47:57 |
| created | [InstanceEdit:925712] Jupe, S, 2010-08-06 |
| height | 1212 |
| modified | [InstanceEdit:1679954] Wu, G, 2011-10-20 [InstanceEdit:1909076] Rothfels, K, 2011-11-01 [InstanceEdit:1984035] Jupe, S, 2011-11-11 [InstanceEdit:2193077] Wu, G, 2012-04-11 [InstanceEdit:8855180] Wu, G, 2016-02-02 [InstanceEdit:8864554] Jupe, Steve, 2016-03-16 [InstanceEdit:8947971] Jupe, Steve, 2016-11-08 [InstanceEdit:9038387] D'Eustachio, Peter, 2018-02-26 [InstanceEdit:9038389] D'Eustachio, Peter, 2018-02-26 [InstanceEdit:9603904] Jassal, Bijay, 2018-03-28 [InstanceEdit:9603926] Jassal, Bijay, 2018-03-28 [InstanceEdit:9645116] Wu, G, 2019-05-03 [InstanceEdit:9676165] Orlic-Milacic, Marija, 2020-02-10 [InstanceEdit:9686320] May, Bruce, 2020-04-30 [InstanceEdit:9686877] May, Bruce, 2020-05-05 [InstanceEdit:9687793] May, Bruce, 2020-05-12 [InstanceEdit:9689766] Matthews, Lisa, 2020-05-21 [InstanceEdit:9699035] Matthews, Lisa, 2020-09-09 [InstanceEdit:9709995] Stephan, Ralf, 2020-12-21 [InstanceEdit:9709996] Stephan, Ralf, 2020-12-21 [InstanceEdit:9710000] Stephan, Ralf, 2020-12-21 [InstanceEdit:9716702] Jassal, Bijay, 2021-02-24 [InstanceEdit:9764678] May, Bruce, 2022-02-13 [InstanceEdit:9768031] Shamovsky, Veronica, 2022-03-03 [InstanceEdit:9773800] Shamovsky, Veronica, 2022-05-10 [InstanceEdit:9773897] Shamovsky, Veronica, 2022-05-10 [InstanceEdit:9892589] May, Bruce, 2024-03-28 |
| representedPathway | [Pathway:168643] Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways [Homo sapiens] |
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</org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="608" reactomeId="1252386" position="731 875" bounds="687 864 88 22" textPosition="687 864" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>IPAF elicitors</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="609" reactomeId="561198" position="638 876" bounds="612 866 53 21" textPosition="615 866"> <Properties> <displayName>NLRC4</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="610" reactomeId="877394" position="684 772" bounds="619 761 131 22" textPosition="619 762" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>IPAF elicitors:NLRC4</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="612" reactomeId="874083" position="829 811" bounds="761 790 137 42" textPosition="762 797" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>IPAF elicitors:NLRC4:Procaspase-1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="666" reactomeId="206255" position="877 1045" bounds="828 1027 99 36" textPosition="832 1027"> <Properties> <displayName>p-S207,T211-MAP2K6</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.2739313037344372" relativeY="1.0" label="P" description="Ser" trackId="0" reactomeId="205959" /> <org.gk.render.RenderableFeature relativeX="0.37833929162344226" relativeY="1.0" label="P" description="Thr" trackId="1" reactomeId="206161" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="668" reactomeId="113592" position="872 973" bounds="853 959 39 29" textPosition="857 963"> <Properties> <displayName>ATP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableEntitySet id="669" reactomeId="1250102" position="985 985" bounds="950 975 70 21" textPosition="950 975"> <Properties> <displayName>p38 MAPK</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="671" reactomeId="1250100" position="986 1167" bounds="922 1157 129 21" textPosition="922 1157"> <Properties> <displayName>Phospho-p38 MAPK</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="672" reactomeId="167998" position="753 927" bounds="724 916 58 22" textPosition="724 916"> <Properties> <displayName>MAP2K6</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="675" reactomeId="29370" position="774 1123" bounds="754 1109 41 29" textPosition="758 1113" /> <org.gk.render.RenderableEntity id="676" reactomeId="1296409" position="1035 675" bounds="965 654 141 43" textPosition="983 658" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>NLRP3 elicitors:NLRP3 oligomer</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableEntity id="677" reactomeId="1296412" position="618 518" bounds="565 501 107 35" textPosition="564 501" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>MDP:NLRP1:ATP oligomer</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableEntity id="678" reactomeId="1296424" position="1337 874" bounds="1295 857 85 35" textPosition="1295 857" bgColor="204 255 204" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>dsDNA:AIM2 oligomer</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableComplex id="680" reactomeId="1306879" position="946 386" bounds="894 368 104 36" textPosition="894 369" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>NLRP3 elicitor proteins:NLRP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="745" reactomeId="1306878" position="770 414" bounds="718 396 105 36" textPosition="718 396" bgColor="204 255 255" fgColor="0 0 0" lineColor="255 0 0"> <Properties> <displayName>NLRP3 elicitors:NLRP3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="747" reactomeId="168113" position="364 1017" bounds="322 1000 85 35" textPosition="323 1000" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CHUK:IKBKB:IKBKG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="751" reactomeId="772536" position="465 1101" bounds="418 1083 94 36" textPosition="417 1083" bgColor="204 255 255"> <Properties> <displayName>Activated TAK complexes</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableComplex id="759" reactomeId="8947970" position="57 987" bounds="9 976 96 22" textPosition="10 977" bgColor="204 255 255" hideComponents="true" /> <org.gk.render.RenderableEntitySet id="760" reactomeId="9038383" position="949 248" bounds="903 230 93 36" textPosition="901 230" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>NLRP3 elicitor proteins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableCompartment id="763" reactomeId="7660" position="1320 478" bounds="1213 383 215 190" textPosition="1320 398" bgColor="250 240 240" lineColor="255 153 102" insets="1222 395 197 168"> <Properties> <displayName>nucleoplasm</displayName> </Properties> <Components> <Component id="765" /> <Component id="764" /> <Component id="768" /> </Components> </org.gk.render.RenderableCompartment> <org.gk.render.RenderableGene id="765" reactomeId="9603902" position="1277 527" bounds="1238 502 79 51" textPosition="1252 529"> <Properties> <displayName>NLRP3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableComplex id="768" reactomeId="177673" position="1360 452" bounds="1307 428 106 49" textPosition="1309 428" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>NFKB1(1-433), NFKB2(1-454):RELA</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="773" reactomeId="9674636" position="314 225" bounds="288 214 52 22" textPosition="293 214"> <Properties> <displayName>AAMP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="774" reactomeId="9676152" position="352 329" bounds="310 318 85 22" textPosition="312 319" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>AAMP:NOD2</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="776" reactomeId="73668" position="1512 231" bounds="1469 218 86 27" textPosition="1479 221"> <Properties> <displayName>2xHC-TXN</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.18604651162790697" relativeY="0.0" label="SS" trackId="0" reactomeId="111706" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="793" reactomeId="1250285" position="1065 227" bounds="1018 216 94 22" textPosition="1022 217" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>TXNIP:NLRP3</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="794" reactomeId="9609901" position="1196 271" bounds="1167 260 58 22" textPosition="1170 260"> <Properties> <displayName>HMOX1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="795" reactomeId="741389" position="380 818" bounds="318 790 124 56" textPosition="318 797" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>PAMP:NOD oligomer:RIP2:K63-Ub-K285-NEMO</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="796" reactomeId="9755930" position="524 910" bounds="459 899 131 23" textPosition="460 901" bgColor="204 255 255" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>N:CHUK:IKBKB:IKBKG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="797" reactomeId="9755745" position="447 880" bounds="396 869 103 23" textPosition="396 871" bgColor="204 255 255" lineColor="255 0 0" hideComponents="true"> <Properties> <displayName>N:TAK1complex</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.ProcessNode id="800" reactomeId="9705683" position="542 810" bounds="480 788 125 45" textPosition="480 789" lineColor="255 0 0" isForDisease="true"> <Properties> <displayName>SARS-CoV-2-host interactions</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableChemical id="805" reactomeId="113592" position="406 956" bounds="386 941 40 31" textPosition="390 946" /> <org.gk.render.RenderableChemical id="806" reactomeId="29370" position="533 957" bounds="513 942 41 31" textPosition="517 947"> <Properties> <displayName>ADP</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableComplex id="807" reactomeId="202513" position="569 1035" bounds="507 1017 125 37" textPosition="512 1019" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>CHUK:p-S177,S181-IKBKB:IKBKG</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="808" reactomeId="9855178" position="1175 121" bounds="1127 104 97 34" textPosition="1141 103" bgColor="204 255 255" hideComponents="true" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="2" reactomeId="168400" points="265 213, 265 249, 267 280" position="265 249" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="3" points="291 197" /> <Input id="4" points="231 190" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> <Properties> <displayName>iE-DAP elicits a NOD1 response</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="7" reactomeId="168412" points="431 225, 430 253, 431 282" position="430 253" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="8" points="392 194" /> <Input id="9" points="463 197" /> </Inputs> <Outputs> <Output id="10" /> </Outputs> <Properties> <displayName>MDP elicits a NOD2 response</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="11" reactomeId="622310" points="267 308, 267 347, 267 368" position="267 347" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="5" stoichiometry="6" /> </Inputs> <Outputs> <Output id="12" /> </Outputs> <Properties> <displayName>Activated NOD1 oligomerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="13" reactomeId="708349" points="432 311, 432 344, 432 366" position="432 344" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="10" stoichiometry="6" /> </Inputs> <Outputs> <Output id="14" /> </Outputs> <Properties> <displayName>Activated NOD2 oligomerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="15" reactomeId="168405" points="354 475, 354 496, 354 524" position="354 496" lineWidth="0.5" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="16" stoichiometry="6" points="264 460" /> <Input id="17" points="356 459" /> </Inputs> <Outputs> <Output id="18" /> </Outputs> <Properties> <displayName>Activated NOD oligomer recruites RIP2 (RICK)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="28" reactomeId="622415" points="352 586, 353 605, 353 627" position="353 605" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="29" points="260 569" /> <Input id="18" points="353 568" /> </Inputs> <Outputs> <Output id="30" /> </Outputs> <Properties> <displayName>RIP2 binds NEMO</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="31" reactomeId="741386" points="356 708, 357 740, 371 787" position="357 740" lineWidth="1.0" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="30" points="354 680" /> <Input id="32" points="264 697" /> </Inputs> <Outputs> <Output id="795" /> </Outputs> <Catalysts> <Catalyst id="156" points="158 794" /> </Catalysts> <Properties> <displayName>RIP2 induces K63-linked ubiquitination of NEMO</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="34" reactomeId="741411" points="379 787, 379 738, 379 700" position="379 738" lineWidth="1.0" lineColor="255 0 0"> <Inputs> <Input id="795" /> </Inputs> <Outputs> <Output id="30" points="366 680" /> <Output id="32" points="264 694" /> </Outputs> <Catalysts> <Catalyst id="35" points="410 738" /> </Catalysts> <Properties> <displayName>CYLD deubiquitinates NEMO</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="36" reactomeId="688137" points="264 791, 267 838, 269 895" position="267 838" lineWidth="1.0" lineColor="255 0 0" reactionType="Transition"> <Inputs> <Input id="30" points="338 680" /> <Input id="32" stoichiometry="6" points="204 706" /> </Inputs> <Outputs> <Output id="37" /> </Outputs> <Catalysts> <Catalyst id="157" points="134 906" /> </Catalysts> <Properties> <displayName>RIP2 is K63 polyubiquitinated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="39" reactomeId="688136" points="250 895, 202 833, 199 776" position="202 833" lineWidth="1.0" lineColor="255 0 0" reactionType="Transition"> <Inputs> <Input id="37" /> </Inputs> <Outputs> <Output id="30" points="324 680" /> <Output id="32" stoichiometry="6" points="196 706" /> </Outputs> <Catalysts> <Catalyst id="40" points="174 842" /> </Catalysts> <Properties> <displayName>TNFAIP3 (A20) deubiquitinates RIP2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="41" reactomeId="688985" points="172 970, 170 1024, 107 1071" position="170 1024" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="37" points="213 954" /> <Input id="759" points="108 979" /> </Inputs> <Outputs> <Output id="43" /> </Outputs> <Properties> <displayName>K63 polyubiquitinated RIP2 associates with the TAK1 complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="45" reactomeId="706479" points="133 1104, 184 1104, 239 1104" position="184 1104" lineWidth="1.0" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="43" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> <Properties> <displayName>TAK1 is activated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="53" reactomeId="622420" points="169 321, 152 338, 136 368" position="152 338" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="5" points="227 308" /> <Input id="491" points="134 307" /> </Inputs> <Outputs> <Output id="55" /> </Outputs> <Properties> <displayName>NOD1 induced apoptosis is mediated by RIP2 and CARD8</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="56" reactomeId="741395" points="443 589, 466 604, 510 633" position="466 604" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="18" points="393 568" /> <Input id="57" points="474 559" /> </Inputs> <Outputs> <Output id="58" /> </Outputs> <Properties> <displayName>CARD9 binds RIP2 (and NOD2)</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="59" reactomeId="877178" points="721 102, 756 102, 795 113" position="756 102" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="60" points="709 90" /> <Input id="61" points="708 116" /> </Inputs> <Outputs> <Output id="62" /> </Outputs> <Properties> <displayName>ATP binds to P2X7</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="63" reactomeId="877158" points="846 113, 877 95, 940 113" position="877 95" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="62" stoichiometry="3" /> </Inputs> <Outputs> <Output id="64" /> </Outputs> <Properties> <displayName>P2X7 forms oligomeric non-selective cation channels</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="65" reactomeId="877187" points="1093 147, 1093 128, 1071 77" position="1093 128" lineWidth="1.0"> <Inputs> <Input id="66" /> </Inputs> <Outputs> <Output id="67" /> </Outputs> <Catalysts> <Catalyst id="64" points="1047 128" /> </Catalysts> <Properties> <displayName>P2X7 mediates loss of intracellular K+</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="68" reactomeId="877198" points="1211 191, 1246 173, 1287 150" position="1246 173" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="64" points="989 143, 1050 193" /> <Input id="808" points="1183 141" /> </Inputs> <Outputs> <Output id="70" /> </Outputs> <Properties> <displayName>P2X7 mediates membrane pores that include pannexin-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="71" reactomeId="844440" points="1046 278, 1049 324, 1049 347" position="1049 324" lineWidth="1.0" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="760" points="1002 262" /> <Input id="72" points="1059 276" /> </Inputs> <Outputs> <Output id="680" points="993 365" /> <Output id="74" points="1137 504" /> </Outputs> <Properties> <displayName>NLRP3 activation by elicitor proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="76" reactomeId="874087" points="1144 567, 1143 564, 1143 532" position="1143 564" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="77" points="1174 587" /> <Input id="78" points="1103 585" /> </Inputs> <Outputs> <Output id="74" /> </Outputs> <Properties> <displayName>SGT1 binds HSP90</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="106" reactomeId="873951" points="1122 337, 1122 334, 1113 296" position="1122 334" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="74" points="1142 504" /> <Input id="107" points="1209 337" /> </Inputs> <Outputs> <Output id="72" /> </Outputs> <Properties> <displayName>SGT1:HSP90 binds inactive NLRP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="111" reactomeId="844610" points="1119 708, 1147 742, 1152 759" position="1147 742" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="676" points="1089 700" /> <Input id="112" points="1170 690" /> </Inputs> <Outputs> <Output id="113" /> </Outputs> <Properties> <displayName>NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="114" reactomeId="844612" points="1106 837, 1107 876, 1107 906" position="1107 876" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="115" points="772 531" /> <Input id="113" points="1131 816" /> </Inputs> <Outputs> <Output id="116" /> </Outputs> <Properties> <displayName>PYCARD recruits procaspase-1 via CARD</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="117" reactomeId="877361" points="1261 710, 1278 737, 1294 775" position="1278 737" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="112" stoichiometry="3" points="1218 690" /> <Input id="118" points="1280 689" /> </Inputs> <Outputs> <Output id="119" /> </Outputs> <Properties> <displayName>Pyrin binds ASC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="120" reactomeId="879221" points="1344 703, 1363 728, 1408 763" position="1363 728" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="118" points="1319 689" /> <Input id="121" points="1369 688" /> </Inputs> <Outputs> <Output id="122" /> </Outputs> <Properties> <displayName>PSTPIP1 binds Pyrin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="123" reactomeId="879201" points="750 217, 751 264, 752 343" position="751 264" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="124" points="786 206" /> <Input id="125" points="643 182" /> </Inputs> <Outputs> <Output id="126" /> </Outputs> <Properties> <displayName>Bcl-2 and Bcl-XL bind NLRP1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="127" reactomeId="844447" points="552 208, 552 236, 552 271" position="552 236" lineWidth="1.0" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="125" points="593 190" /> <Input id="9" points="503 186" /> </Inputs> <Outputs> <Output id="128" /> </Outputs> <Properties> <displayName>NLRP1 senses MDP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="130" reactomeId="879222" points="618 318, 618 355, 617 393" position="618 355" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="131" points="635 306" /> <Input id="128" points="574 299" /> </Inputs> <Outputs> <Output id="132" /> </Outputs> <Properties> <displayName>MDP:NLRP1 binds ATP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="133" reactomeId="844438" points="617 421, 617 467, 617 498" position="617 467" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="132" /> </Inputs> <Outputs> <Output id="677" /> </Outputs> <Properties> <displayName>NLRP1 oligomerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="135" reactomeId="844608" points="652 569, 687 615, 689 660" position="687 615" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="115" points="737 531" /> <Input id="677" points="629 539" /> </Inputs> <Outputs> <Output id="136" /> </Outputs> <Properties> <displayName>NLRP1 binds procaspase-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="146" reactomeId="844618" points="1072 1021, 1072 1050, 1113 1067" position="1072 1050" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="147" points="1209 1022" /> <Input id="115" points="767 531" /> </Inputs> <Outputs> <Output id="148" /> </Outputs> <Properties> <displayName>dsDNA:AIM2:ASC cluster binds procaspase-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="149" reactomeId="844620" points="1255 916, 1256 965, 1256 1002" position="1256 965" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="112" points="1200 690" /> <Input id="678" points="1302 895" /> </Inputs> <Outputs> <Output id="147" /> </Outputs> <Properties> <displayName>dsDNA:AIM2 clusters bind ASC</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="151" reactomeId="874079" points="1360 964, 1355 940, 1341 895" position="1355 940" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="152" /> </Inputs> <Outputs> <Output id="678" /> </Outputs> <Properties> <displayName>AIM2 oligomerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="153" reactomeId="844619" points="1367 1052, 1365 1023, 1363 992" position="1365 1023" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="154" points="1339 1074" /> <Input id="155" points="1409 1075" /> </Inputs> <Outputs> <Output id="152" /> </Outputs> <Properties> <displayName>AIM2 binds dsDNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="356" reactomeId="1250253" points="1418 177, 1372 180, 1372 208" position="1372 180" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="357" /> </Inputs> <Outputs> <Output id="344" points="1305 194" /> <Output id="776" points="1466 223" /> </Outputs> <Properties> <displayName>TXNIP is released from oxidized thioredoxin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="404" reactomeId="1250264" points="1308 241, 1308 241, 1341 298" position="1308 241" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="344" points="1285 205" /> <Input id="405" points="1329 239" /> </Inputs> <Outputs> <Output id="406" /> </Outputs> <Properties> <displayName>TXNIP binds reduced thioredoxin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="458" reactomeId="1250280" points="1428 267, 1453 267, 1489 248" position="1453 267" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="459" points="1426 288" /> <Input id="405" points="1390 250" /> </Inputs> <Outputs> <Output id="776" /> </Outputs> <Properties> <displayName>ROS oxidize thioredoxin</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="607" reactomeId="874084" points="684 832, 685 810, 684 786" position="685 810" lineWidth="1.0" lineColor="255 0 0" reactionType="Omitted Process"> <Inputs> <Input id="608" points="718 858" /> <Input id="609" points="648 863" /> </Inputs> <Outputs> <Output id="610" /> </Outputs> <Properties> <displayName>IPAF is activated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="611" reactomeId="844617" points="762 707, 806 709, 824 787" position="806 709" lineWidth="1.0" lineColor="255 0 0"> <Inputs> <Input id="115" points="761 531" /> <Input id="610" points="697 758" /> </Inputs> <Outputs> <Output id="612" /> </Outputs> <Properties> <displayName>IPAF binds procaspase-1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="667" reactomeId="1247960" points="951 1030, 950 1082, 951 1121" position="950 1082" lineWidth="1.0"> <Inputs> <Input id="668" stoichiometry="8" points="895 987" /> <Input id="669" points="977 1002" /> </Inputs> <Outputs> <Output id="671" points="978 1151" /> <Output id="675" stoichiometry="8" points="798 1122" /> </Outputs> <Catalysts> <Catalyst id="666" points="886 1066, 896 1083" /> </Catalysts> <Properties> <displayName>Activation of p38 MAPK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="673" reactomeId="727819" points="798 975, 796 1014, 797 1045" position="796 1014" lineWidth="1.0"> <Inputs> <Input id="672" points="763 941" /> <Input id="668" stoichiometry="2" points="850 973" /> </Inputs> <Outputs> <Output id="675" stoichiometry="2" points="778 1106" /> <Output id="666" points="825 1045" /> </Outputs> <Catalysts> <Catalyst id="42" points="756 1016" /> </Catalysts> <Properties> <displayName>TAK1 phosphorylates MKK6</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="743" reactomeId="1306876" points="1079 309, 1080 331, 1079 377" position="1080 331" lineWidth="1.0" lineColor="255 0 0" reactionType="Uncertain Process"> <Inputs> <Input id="73" points="1019 308" /> <Input id="72" points="1092 296" /> </Inputs> <Outputs> <Output id="75" points="989 427" /> <Output id="74" points="1138 504" /> </Outputs> <Properties> <displayName>NLRP3 activation by small molecules</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="744" reactomeId="1296421" points="808 438, 857 455, 1017 651" position="857 455" lineWidth="1.0" lineColor="255 0 0" reactionType="Association"> <Inputs> <Input id="745" /> </Inputs> <Outputs> <Output id="676" /> </Outputs> <Properties> <displayName>NLRP3 oligomerizes via NACHT domains</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="746" reactomeId="168184" points="437 993, 462 992, 488 991" position="462 992" lineWidth="1.0"> <Inputs> <Input id="747" points="410 1003" /> <Input id="805" stoichiometry="2" points="418 975" /> </Inputs> <Outputs> <Output id="806" stoichiometry="2" points="510 972" /> <Output id="807" points="534 1014" /> </Outputs> <Catalysts> <Catalyst id="751" points="464 1077" /> </Catalysts> <Activators> <Activator id="796" points="515 925" /> <Activator id="797" points="442 895, 437 907" /> </Activators> <Properties> <displayName>Activated TAK1 mediates phosphorylation of the IKK Complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="752" points="320 404, 336 411" position="328 407" lineWidth="0.5" lineColor="255 0 0"> <Inputs> <Input id="12" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="753" points="400 405, 383 411" position="391 408" lineWidth="0.5" lineColor="255 0 0"> <Inputs> <Input id="14" /> </Inputs> <Outputs> <Output id="17" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="754" points="374 1102, 412 1101" position="393 1101" lineWidth="1.0" lineColor="255 0 0"> <Inputs> <Input id="46" /> </Inputs> <Outputs> <Output id="751" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="755" points="891 394, 829 405" position="860 399" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="680" /> </Inputs> <Outputs> <Output id="745" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="756" points="888 435, 829 423" position="858 429" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="75" /> </Inputs> <Outputs> <Output id="745" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="757" points="101 837, 101 906" position="101 871" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="156" /> </Inputs> <Outputs> <Output id="157" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="758" points="729 503, 154 307" position="441 405" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="115" /> </Inputs> <Outputs> <Output id="491" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="764" reactomeId="9603905" points="1326 504, 1236 432, 1236 352" position="1236 432" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="765" /> </Inputs> <Outputs> <Output id="107" /> </Outputs> <Activators> <Activator id="768" points="1304 443" /> </Activators> <Properties> <displayName>Expression of NLRP3 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="772" reactomeId="9676160" points="361 237, 356 268, 352 315" position="356 268" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="8" points="375 194" /> <Input id="773" points="343 231" /> </Inputs> <Outputs> <Output id="774" /> </Outputs> <Properties> <displayName>AAMP binds NOD2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="792" reactomeId="1250272" points="1244 226, 1181 226, 1115 226" position="1181 226" lineWidth="1.0"> <Inputs> <Input id="107" points="1236 323" /> <Input id="344" points="1269 205" /> </Inputs> <Outputs> <Output id="793" /> </Outputs> <Inhibitors> <Inhibitor id="794" points="1192 257" /> </Inhibitors> <Properties> <displayName>TXNIP binds NLRP3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="802" interactionType="Activate" points="510 836, 463 866" position="486 851" lineWidth="2.0"> <Inputs> <Input id="800" /> </Inputs> <Outputs> <Output id="797" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="804" interactionType="Activate" points="537 836, 526 896" position="531 866" lineWidth="2.0"> <Inputs> <Input id="800" /> </Inputs> <Outputs> <Output id="796" /> </Outputs> </org.gk.render.RenderableInteraction> </Edges> <Pathways /> </Process> |
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No pathways have been reviewed or authored by Diagram of Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (925713)
