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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

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Details on Person Diagram of Interleukin-3, Interleukin-5 and GM-CSF signaling

Class:IdPathwayDiagram:921156
_displayNameDiagram of Interleukin-3, Interleukin-5 and GM-CSF signaling
_timestamp2021-04-07 08:36:45
created[InstanceEdit:921158] Jupe, S, 2010-08-05
height2104
modified[InstanceEdit:1679954] Wu, G, 2011-10-20
[InstanceEdit:1837315] Jupe, S, 2011-10-27
[InstanceEdit:2193078] Wu, G, 2012-04-11
[InstanceEdit:2753859] May, B, 2012-12-08
[InstanceEdit:4127470] Gillespie, ME, 2013-08-14
[InstanceEdit:5603456] Jupe, Steve, 2014-07-02
[InstanceEdit:5622091] Matthews, Lisa, 2014-09-10
[InstanceEdit:5693756] Jupe, Steve, 2015-05-18
[InstanceEdit:5693757] Jupe, Steve, 2015-05-18
[InstanceEdit:8855180] Wu, G, 2016-02-02
[InstanceEdit:8858401] Jupe, Steve, 2016-02-19
[InstanceEdit:8875631] D'Eustachio, Peter, 2016-06-08
[InstanceEdit:8939791] Jupe, Steve, 2016-09-21
[InstanceEdit:8959628] Duenas, Corina, 2017-01-30
[InstanceEdit:8980586] Jupe, Steve, 2017-02-28
[InstanceEdit:9020559] Duenas, Corina, 2017-09-07
[InstanceEdit:9025966] Jupe, Steve, 2017-10-16
[InstanceEdit:9028816] Jupe, Steve, 2017-11-10
[InstanceEdit:9032255] Orlic-Milacic, Marija, 2017-12-08
[InstanceEdit:9032256] Orlic-Milacic, Marija, 2017-12-08
[InstanceEdit:9032257] Orlic-Milacic, Marija, 2017-12-08
[InstanceEdit:9605381] Varusai, Thawfeek, 2018-04-10
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9726408] Stephan, Ralf, 2021-04-07
representedPathway[Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Homo sapiens]
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</NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="359" reactomeId="912755" position="1165 1890" bounds="1102 1871 126 38" textPosition="1107 1873" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p(Y700,731,774)-CBL:VAV1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntity id="361" reactomeId="912740" position="813 1238" bounds="753 1224 120 29" textPosition="777 1227"> <Properties> <displayName>K48polyUb</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableComplex id="362" reactomeId="912799" position="880 1071" bounds="820 1030 121 83" textPosition="819 1035" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="365" reactomeId="912774" position="1194 1697" bounds="1131 1678 126 38" textPosition="1136 1680" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p(Y700,731,774)-CBL:CRK</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="367" reactomeId="913472" position="1202 1623" bounds="1170 1612 65 22" textPosition="1172 1612"> <Properties> <displayName>RAPGEF1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="368" reactomeId="914209" position="1401 1647" bounds="1338 1628 126 38" textPosition="1343 1630" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>p(Y700,731,774)-CBL:CRK:RAPGEF1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="370" reactomeId="912750" position="1007 1762" bounds="985 1752 45 21" textPosition="988 1752"> <Properties> <displayName>BLNK</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="371" reactomeId="912760" position="1231 1806" bounds="1165 1781 132 50" textPosition="1165 1795" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>B-cell linker protein:p(Y700,731,774)-CBL</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="382" reactomeId="57844" position="482 806" bounds="454 795 56 22" textPosition="454 795"> <Properties> <displayName>PRKACA</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.ProcessNode id="453" reactomeId="5673001" position="1619 1664" bounds="1558 1635 122 59" textPosition="1562 1642"> <Properties> <displayName>RAF/MAP kinase cascade</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableEntitySet id="455" reactomeId="381945" position="942 1669" bounds="907 1658 71 22" textPosition="907 1658"> <Properties> <displayName>CRK, CRKL</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntity id="456" reactomeId="8939790" position="1669 730" bounds="1616 712 107 36" textPosition="1616 712"> <Properties> <displayName>Unkown tyrosine kinase</displayName> </Properties> </org.gk.render.RenderableEntity> <org.gk.render.RenderableEntitySet id="458" reactomeId="8958305" position="654 1247" bounds="594 1208 121 78" textPosition="603 1222"> <Properties> <displayName>IL3 upregulated extracellular protein genes</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="459" reactomeId="8957977" position="106 1216" bounds="55 1182 102 69" textPosition="55 1191"> <Properties> <displayName>IL3 upregulated extracellular proteins</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="473" reactomeId="9726394" position="1094 86" bounds="1057 70 74 32" textPosition="1060 68" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" /> <org.gk.render.RenderableComplex id="474" reactomeId="9726405" position="1332 135" bounds="1275 116 114 39" textPosition="1282 119" bgColor="184 154 230" fgColor="161 1 2" isForDrug="true" hideComponents="true" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="2" reactomeId="879937" points="318 290, 317 326, 289 361" position="317 326" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="3" points="296 270" /> <Input id="4" points="356 288" /> </Inputs> <Outputs> <Output id="5" /> </Outputs> <Properties> <displayName>The common beta chain IL3RB binds JAK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="6" reactomeId="913360" points="821 214, 842 213, 865 223" position="842 213" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="7" points="782 242" /> <Input id="8" points="792 205" /> </Inputs> <Outputs> <Output id="9" /> </Outputs> <Properties> <displayName>GM-CSF receptor alpha subunit binds GM-CSF</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="12" reactomeId="913371" points="1068 371, 1194 370, 1449 275" position="1194 370" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="9" points="955 277" /> <Input id="5" points="331 376" /> </Inputs> <Outputs> <Output id="13" /> </Outputs> <Properties> <displayName>GM-CSF receptor alpha:GM-CSF binds Bc</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="14" reactomeId="879942" points="293 872, 293 905, 293 935" position="293 905" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="15" stoichiometry="2" /> </Inputs> <Outputs> <Output id="16" /> </Outputs> <Properties> <displayName>The receptor is activated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="17" reactomeId="913446" points="972 183, 1020 183, 1053 183" position="1020 183" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="18" stoichiometry="2" /> </Inputs> <Outputs> <Output id="19" /> </Outputs> <Properties> <displayName>Interleukin-5 is a homodimer</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="20" reactomeId="913456" points="1139 219, 1174 218, 1185 239" position="1174 218" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="19" points="1116 197" /> <Input id="21" points="1106 243" /> </Inputs> <Outputs> <Output id="22" /> </Outputs> <Properties> <displayName>Interleukin-5 receptor alpha subunit binds Interleukin-5</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="23" reactomeId="913370" points="1338 410, 1451 408, 1649 280" position="1451 408" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="22" points="1211 281" /> <Input id="5" points="331 378" /> </Inputs> <Outputs> <Output id="24" /> </Outputs> <Properties> <displayName>Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="25" reactomeId="450074" points="568 222, 588 224, 616 243" position="588 224" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="26" points="557 240" /> <Input id="27" points="535 208" /> </Inputs> <Outputs> <Output id="28" /> </Outputs> <Properties> <displayName>Interleukin-3 receptor alpha subunit binds Interleukin-3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="29" reactomeId="450031" points="797 344, 1135 342, 1302 275" position="1135 342" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="28" points="652 272" /> <Input id="5" points="331 373" /> </Inputs> <Outputs> <Output id="30" /> </Outputs> <Properties> <displayName>Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="40" reactomeId="879910" points="373 1043, 372 1067, 373 1095" position="372 1067" lineWidth="1.0"> <Inputs> <Input id="41" stoichiometry="6" points="399 1022" /> <Input id="16" points="347 1030" /> </Inputs> <Outputs> <Output id="42" stoichiometry="6" points="397 1109" /> <Output id="43" points="349 1107" /> </Outputs> <Catalysts> <Catalyst id="16" points="311 1030, 329 1066" /> </Catalysts> <Properties> <displayName>JAK2 is phosphorylated, activated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="44" reactomeId="879930" points="367 1205, 368 1228, 348 1240" position="368 1228" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="43" points="353 1202" /> <Input id="45" stoichiometry="3" points="403 1192" /> </Inputs> <Outputs> <Output id="46" /> </Outputs> <Properties> <displayName>STAT5 is recruited by JAK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="47" reactomeId="879909" points="374 1360, 374 1386, 375 1413" position="374 1386" lineWidth="1.0"> <Inputs> <Input id="46" points="342 1335" /> <Input id="48" stoichiometry="6" points="401 1342" /> </Inputs> <Outputs> <Output id="49" stoichiometry="6" points="403 1432" /> <Output id="50" points="329 1461" /> </Outputs> <Catalysts> <Catalyst id="46" points="303 1335, 305 1386" /> </Catalysts> <Properties> <displayName>Activation of STAT5a/b by JAK2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="51" reactomeId="452102" points="467 1504, 495 1504, 522 1503" position="495 1504" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="52" stoichiometry="2" /> </Inputs> <Outputs> <Output id="53" /> </Outputs> <Properties> <displayName>p-STAT5 dimerizes</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="54" reactomeId="921155" points="259 1461, 205 1400, 203 1320" position="205 1400" lineWidth="1.0" reactionType="Dissociation"> <Inputs> <Input id="50" /> </Inputs> <Outputs> <Output id="52" stoichiometry="3" points="400 1484" /> <Output id="43" points="256 1202, 205 1252" /> </Outputs> <Properties> <displayName>p-STAT5 dissociates from the receptor complex</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="56" reactomeId="879907" points="1694 372, 1695 396, 1694 425" position="1695 396" lineWidth="1.0"> <Inputs> <Input id="16" points="366 953" /> <Input id="57" stoichiometry="12" points="1663 352" /> </Inputs> <Outputs> <Output id="58" points="1720 436" /> <Output id="59" stoichiometry="12" points="1663 464" /> </Outputs> <Catalysts> <Catalyst id="60" points="1761 366, 1732 395" /> </Catalysts> <Properties> <displayName>Tyrosine kinases phosphorylate the receptor</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="61" reactomeId="879934" points="1768 532, 1767 566, 1777 600" position="1767 566" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="62" stoichiometry="3" points="1735 543" /> <Input id="58" points="1783 513" /> </Inputs> <Outputs> <Output id="63" /> </Outputs> <Properties> <displayName>Recruitment of SHC1 is mediated by Y593 of the common beta chain</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="64" reactomeId="879925" points="1790 710, 1790 732, 1790 761" position="1790 732" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="63" /> </Inputs> <Outputs> <Output id="65" /> </Outputs> <Catalysts> <Catalyst id="456" points="1726 730" /> </Catalysts> <Properties> <displayName>SHC1 bound to the common beta chain becomes tyrosine phosphorylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="67" reactomeId="453104" points="1785 987, 1791 1004, 1807 1021" position="1791 1004" lineWidth="1.0" reactionType="Uncertain Process"> <Inputs> <Input id="308" stoichiometry="4" points="1668 982" /> <Input id="68" points="1792 968" /> </Inputs> <Outputs> <Output id="69" /> </Outputs> <Properties> <displayName>Phosphorylated SHC1 recruits GRB2:GAB2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="75" reactomeId="912527" points="1793 1124, 1793 1143, 1793 1163" position="1793 1143" lineWidth="1.0"> <Inputs> <Input id="69" points="1811 1097" /> <Input id="309" stoichiometry="4" points="1751 1124" /> </Inputs> <Outputs> <Output id="76" points="1802 1179" /> <Output id="310" stoichiometry="4" points="1752 1163" /> </Outputs> <Properties> <displayName>SHC1 mediates cytokine-induced phosphorylation of GAB2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="79" reactomeId="508247" points="1790 1275, 1789 1313, 1790 1343" position="1789 1313" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="80" stoichiometry="4" points="1312 1118" /> <Input id="76" points="1801 1255" /> </Inputs> <Outputs> <Output id="81" /> </Outputs> <Properties> <displayName>Gab2 binds the p85 subunit of Class 1A PI3 kinases</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="83" reactomeId="453111" points="1587 1362, 1586 1483, 1727 1523" position="1586 1483" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="84" stoichiometry="4" points="1537 1329" /> <Input id="68" points="1786 968" /> </Inputs> <Outputs> <Output id="155" /> </Outputs> <Properties> <displayName>Phosphorylated SHC recruits GRB2:SOS1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="210" reactomeId="913374" points="1432 1248, 1518 1849, 1520 2014" position="1518 1849" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="68" points="1764 968" /> <Input id="211" stoichiometry="4" points="1380 1201" /> </Inputs> <Outputs> <Output id="212" /> </Outputs> <Properties> <displayName>Phosphorylated SHC1 recruits SHIP</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="283" reactomeId="913424" points="694 2043, 718 2043, 765 2051" position="718 2043" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="284" stoichiometry="4" points="648 1980" /> <Input id="285" points="667 2048" /> </Inputs> <Outputs> <Output id="286" /> </Outputs> <Properties> <displayName>The SHC1:SHIP1 complex is stabilized by GRB2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="287" reactomeId="909738" points="554 1608, 405 1610, 348 1629" position="405 1610" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="288" points="585 1641" /> <Input id="58" points="1720 499, 740 877, 744 1500" /> </Inputs> <Outputs> <Output id="289" /> </Outputs> <Properties> <displayName>SHP1 and SHP2 bind the common beta chain</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="290" reactomeId="914036" points="278 1702, 278 1748, 278 1778" position="278 1748" lineWidth="1.0"> <Inputs> <Input id="289" /> </Inputs> <Outputs> <Output id="291" /> </Outputs> <Catalysts> <Catalyst id="289" points="253 1702, 228 1747" /> </Catalysts> <Properties> <displayName>SHP1 and SHP2 dephosphorylate Y628 of IL3RB</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="293" reactomeId="914022" points="555 1918, 525 1917, 483 1916" position="525 1917" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="284" points="621 1952" /> <Input id="294" points="590 1739" /> </Inputs> <Outputs> <Output id="295" /> </Outputs> <Properties> <displayName>SHP2 can recruit GRB2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="296" reactomeId="913451" points="334 935, 401 871, 404 809, 334 743" position="404 809" lineWidth="1.0"> <Inputs> <Input id="16" /> </Inputs> <Outputs> <Output id="297" /> </Outputs> <Catalysts> <Catalyst id="382" points="451 807" /> </Catalysts> <Properties> <displayName>IL3RB is phosphorylated on Ser-585</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="299" reactomeId="912757" points="400 647, 400 606, 363 599" position="400 606" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="300" points="427 657" /> <Input id="297" points="366 665" /> </Inputs> <Outputs> <Output id="301" /> </Outputs> <Properties> <displayName>p-S585-IL3RB binds 14-3-3 proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="302" reactomeId="879914" points="970 1973, 970 1987, 971 2021" position="970 1987" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="303" points="988 1948" /> <Input id="304" points="950 1948" /> </Inputs> <Outputs> <Output id="305" /> </Outputs> <Properties> <displayName>IL3 stimulation induces Vav binding to Tec kinase</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="306" reactomeId="914182" points="405 527, 404 478, 381 474" position="404 478" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="80" points="1232 1070" /> <Input id="301" points="363 552" /> </Inputs> <Outputs> <Output id="307" /> </Outputs> <Properties> <displayName>14-3-3 zeta binding allows recruitment of PI3K</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="311" reactomeId="507937" points="562 1481, 562 1423, 562 1362" position="562 1423" lineWidth="1.0"> <Inputs> <Input id="53" /> </Inputs> <Outputs> <Output id="312" /> </Outputs> <Properties> <displayName>STAT5 dimers translocate to the nucleus</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="314" reactomeId="879917" points="764 1790, 849 1610, 901 1489" position="849 1610" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="284" points="648 1952" /> <Input id="315" points="718 1793" /> <Input id="80" points="1247 1118" /> <Input id="316" points="760 1866" /> </Inputs> <Outputs> <Output id="317" /> </Outputs> <Properties> <displayName>CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="352" reactomeId="912629" points="860 1395, 859 1357, 860 1325" position="859 1357" lineWidth="1.0"> <Inputs> <Input id="353" stoichiometry="3" points="828 1417" /> <Input id="317" points="882 1415" /> </Inputs> <Outputs> <Output id="354" points="928 1285" /> <Output id="355" stoichiometry="3" points="836 1306" /> </Outputs> <Catalysts> <Catalyst id="317" points="915 1415, 914 1358" /> </Catalysts> <Properties> <displayName>CBL is tyrosine phosphorylated</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="357" reactomeId="912727" points="1029 1889, 1064 1889, 1099 1889" position="1064 1889" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="358" points="921 1834" /> <Input id="303" points="1004 1919" /> </Inputs> <Outputs> <Output id="359" /> </Outputs> <Properties> <displayName>CBL binds VAV</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="360" reactomeId="912627" points="882 1201, 881 1163, 880 1116" position="881 1163" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="354" points="916 1218" /> <Input id="361" points="840 1221" /> </Inputs> <Outputs> <Output id="362" /> </Outputs> <Properties> <displayName>CBL ubiquitinates PI3K</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="363" reactomeId="912790" points="997 1698, 1060 1697, 1128 1697" position="1060 1697" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="455" points="962 1686" /> <Input id="358" points="903 1778" /> </Inputs> <Outputs> <Output id="365" /> </Outputs> <Properties> <displayName>CBL binds CRK</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="366" reactomeId="912734" points="1267 1644, 1302 1643, 1335 1644" position="1302 1643" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="365" points="1220 1675" /> <Input id="367" points="1238 1633" /> </Inputs> <Outputs> <Output id="368" /> </Outputs> <Properties> <displayName>CBL:CRKL binds RAPGEF1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="369" reactomeId="912724" points="1051 1805, 1101 1805, 1162 1805" position="1101 1805" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="370" points="1017 1776" /> <Input id="358" points="935 1805" /> </Inputs> <Outputs> <Output id="371" /> </Outputs> <Properties> <displayName>CBL binds B-cell linker protein</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="372" points="593 1710, 595 1682" position="594 1696" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="294" /> </Inputs> <Outputs> <Output id="288" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="373" points="1795 886, 1796 892" position="1795 889" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="65" /> </Inputs> <Outputs> <Output id="68" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="374" points="1570 236, 1752 182, 1780 290" position="1752 182" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="13" /> </Inputs> <Outputs> <Output id="60" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="375" points="1728 280, 1748 290" position="1738 285" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="24" /> </Inputs> <Outputs> <Output id="60" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="376" points="1313 275, 366 788" position="839 531" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="30" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="377" points="1449 281, 366 793" position="907 537" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="13" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="378" points="1633 271, 366 796" position="999 533" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="24" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="379" points="1730 366, 366 1118" position="1048 742" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="43" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndEntitySetLink id="380" points="1716 350, 366 802" position="1041 576" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="60" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableInteraction id="454" interactionType="Activate" points="1740 1579, 1660 1632" position="1700 1605" lineWidth="2.0"> <Inputs> <Input id="155" /> </Inputs> <Outputs> <Output id="453" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="457" reactomeId="8958317" points="588 1232, 520 1215, 163 1215" position="520 1215" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="458" /> </Inputs> <Outputs> <Output id="459" /> </Outputs> <Activators> <Activator id="27" points="519 218" /> </Activators> <Properties> <displayName>Expression of IL3-upregulated extracellular proteins</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="465" points="1363 231, 1413 172, 1784 170, 1787 290" position="1598 171" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="30" /> </Inputs> <Outputs> <Output id="60" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="472" reactomeId="9726409" points="1177 134, 1223 134, 1272 134" position="1223 134" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="19" points="1121 169" /> <Input id="473" points="1121 108" /> </Inputs> <Outputs> <Output id="474" /> </Outputs> </org.gk.render.RenderableReaction> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of Interleukin-3, Interleukin-5 and GM-CSF signaling (921156)
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