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Details on Person Recruitment of TRAF3 to MAVS

Class:Id	Reaction:918227
_displayName	Recruitment of TRAF3 to MAVS
_doRelease	TRUE
_timestamp	2023-05-18 15:06:47
authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:918228] Garapati, P V, 2010-08-02
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
input	[Complex:918201] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] [Homo sapiens] [EntityWithAccessionedSequence:936402] K63polyUb-TRAF3 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:918158] Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif [LiteratureReference:918164] Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response [LiteratureReference:918205] Antiviral signaling through pattern recognition receptors
modified	[InstanceEdit:933522] Garapati, P V, 2010-08-16 [InstanceEdit:936409] Garapati, P V, 2010-08-22 [InstanceEdit:990524] Garapati, P V, 2010-11-03 [InstanceEdit:994081] Garapati, P V, 2010-11-05 [InstanceEdit:998145] Garapati, P V, 2010-11-09 [InstanceEdit:1022090] Garapati, P V, 2010-11-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8983918] Jupe, Steve, 2017-03-31 [InstanceEdit:9014715] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9038753] Orlic-Milacic, Marija, 2018-03-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9835849] Shamovsky, Veronica, 2023-05-18
name	Recruitment of TRAF3 to MAVS
output	[Complex:918200] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] [Homo sapiens]
precedingEvent	[Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS [Homo sapiens] [Reaction:918224] DDX58 is K63 polyubiquitinated [Homo sapiens] [Reaction:913725] viral dsRNA binds IFIH1:TKFC [Homo sapiens]
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105809] R-HSA-918227.6
summation	[Summation:918146] TRAF3 a E3 ligase for K63-linked polyubiquitination, is one ...
(hasEvent)	[Pathway:918233] TRAF3-dependent IRF activation pathway [Homo sapiens]
(inferredFrom)	[Reaction:1227891] TRAF3/or TRAF6 interacts with IPS-1 [Gallus gallus] [BlackBoxEvent:1227893] TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex [Gallus gallus]
(precedingEvent)	[Reaction:918225] TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 [Homo sapiens] [Reaction:936381] OTUD5 deubiquitinates TRAF3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9928422] Update Tracker - [Reaction:918227] Recruitment of TRAF3 to MAVS - v91:[modifyText]
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No pathways have been reviewed or authored by Recruitment of TRAF3 to MAVS (918227)