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Details on Person ABCG2 tetramer transports heme from cytosol to extracellular region

Class:Id	Reaction:917979
_displayName	ABCG2 tetramer transports heme from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2025-06-11 19:59:37
authored	[InstanceEdit:917867] Stephan, R, 2010-07-07
catalystActivity	[CatalystActivity:917884] ABC-type heme transporter activity of ABCG2 tetramer [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
edited	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
input	[SimpleEntity:71185] ferroheme [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9661436] Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2 [LiteratureReference:917942] The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme [LiteratureReference:917914] Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2) [LiteratureReference:994083] The expression and functional characterization of ABCG2 in brain endothelial cells and vessels
modified	[InstanceEdit:984583] Jassal, Bijay, 2010-11-02 [InstanceEdit:994066] Jassal, Bijay, 2010-11-05 [InstanceEdit:994086] Jassal, Bijay, 2010-11-05 [InstanceEdit:5691161] Jassal, Bijay, 2015-05-05 [InstanceEdit:9661421] Jassal, Bijay, 2019-09-16 [InstanceEdit:9661808] Jassal, Bijay, 2019-09-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9853901] D'Eustachio, Peter, 2023-11-21 [InstanceEdit:9854167] D'Eustachio, Peter, 2023-11-22 [InstanceEdit:9861289] D'Eustachio, Peter, 2024-02-16 [InstanceEdit:9955836] D'Eustachio, Peter, 2025-06-11
name	ABCG2 tetramer transports heme from cytosol to extracellular region ATP + H2O + heme b(in) => ADP + H(+) + heme b(out) + phosphate Export of heme to the blood by ABCG2
output	[SimpleEntity:917877] heme [extracellular region] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:9661408] FLVCR1-2 transports heme from mitochondrial matrix to cytosol [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2010-12-14
reviewed	[InstanceEdit:994085] D'Eustachio, P, 2010-11-05 [InstanceEdit:9861286] Hill, David P, 2024-02-16
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9661807] Jassal, Bijay, 2019-09-18 [InstanceEdit:9854168] D'Eustachio, Peter, 2023-11-22
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104982] R-HSA-917979.5
structureModified	[InstanceEdit:9853901] D'Eustachio, Peter, 2023-11-21
summation	[Summation:917908] Heme is utilised as a prosthetic group in the production of ...
(hasEvent)	[Pathway:189451] Heme biosynthesis [Homo sapiens] [Pathway:917937] Iron uptake and transport [Homo sapiens]
(precedingEvent)	[Reaction:9661419] ALB binds extracellular heme [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777410] Update Tracker - [Reaction:917979] ABCG2 tetramer transports heme from cytosol to extracellular region - v71:[addLiteratureReference, modifyText] [_UpdateTracker:9864333] Update Tracker - [Reaction:917979] ABCG2 tetramer transports heme from cytosol to extracellular region - v88:[addOutput]
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