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Details on Person Fe3+ dissociates from holoTF:TFRC dimer

Class:Id	Reaction:917835
_displayName	Fe3+ dissociates from holoTF:TFRC dimer
_doRelease	TRUE
_timestamp	2015-05-05 12:49:04
authored	[InstanceEdit:917986] Stephan, R, 2010-07-14
compartment	[Compartment:171907] endosome lumen [Compartment:74700] endosome membrane
created	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
edited	[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
input	[Complex:917799] holoTF:TFRC dimer [endosome membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:917875] The mechanism of iron release from the transferrin-receptor 1 adduct
modified	[InstanceEdit:984583] Jassal, Bijay, 2010-11-02 [InstanceEdit:994086] Jassal, Bijay, 2010-11-05 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:5691161] Jassal, Bijay, 2015-05-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Fe3+ dissociates from holoTF:TFRC dimer
output	[Complex:917912] apoTF:TFRC dimer [endosome membrane] [Homo sapiens] [SimpleEntity:917966] Fe3+ [endosome lumen] [SimpleEntity:917966] Fe3+ [endosome lumen] [SimpleEntity:917966] Fe3+ [endosome lumen] [SimpleEntity:917966] Fe3+ [endosome lumen]
precedingEvent	[Reaction:917841] Acidification of Tf:TfR1 containing endosome [Homo sapiens] [BlackBoxEvent:917807] holoTF:TFRC dimer translocates from plasma membrane to endosome membrane [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:994085] D'Eustachio, P, 2010-11-05
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105448] R-HSA-917835.2
summation	[Summation:917967] When endosomal pH reaches 6,0, protons replace the iron ions...
(hasEvent)	[Pathway:917977] Transferrin endocytosis and recycling [Homo sapiens]
(precedingEvent)	[Reaction:917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ [Homo sapiens] [Reaction:917814] apoTF:TFRC dimer translocates from endosome membrane to plasma membrane [Homo sapiens]
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No pathways have been reviewed or authored by Fe3+ dissociates from holoTF:TFRC dimer (917835)