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Details on Person STEAP3,STEAP4 reduce Fe3+ to Fe2+

Class:IdReaction:917811
_displayNameSTEAP3,STEAP4 reduce Fe3+ to Fe2+
_doReleaseTRUE
_timestamp2024-02-20 18:30:25
authored[InstanceEdit:917986] Stephan, R, 2010-07-14
catalystActivity[CatalystActivity:917825] ferric-chelate reductase (NADPH) activity of STEAP3,STEAP4 [endosome membrane]
compartment[Compartment:171907] endosome lumen
[Compartment:74700] endosome membrane
created[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
crossReference[DatabaseIdentifier:9861424] RHEA:71769
edited[InstanceEdit:917843] Jassal, Bijay, 2010-07-30
input[SimpleEntity:111736] Fe3+ [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
internalReviewed[InstanceEdit:9861446] D'Eustachio, Peter, 2024-02-20
isChimericFALSE
literatureReference[LiteratureReference:917953] Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
[LiteratureReference:917932] The Steap proteins are metalloreductases
[LiteratureReference:9861422] Characterization of a single b-type heme, FAD, and metal binding sites in the transmembrane domain of six-transmembrane epithelial antigen of the prostate (STEAP) family proteins
[LiteratureReference:9861423] Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction
modified[InstanceEdit:984583] Jassal, Bijay, 2010-11-02
[InstanceEdit:994086] Jassal, Bijay, 2010-11-05
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5691161] Jassal, Bijay, 2015-05-05
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9861414] Stephan, Ralf, 2024-02-20
[InstanceEdit:9861445] D'Eustachio, Peter, 2024-02-20
nameSTEAP3,STEAP4 reduce Fe3+ to Fe2+
2 Fe(3+) + NADPH => 2 Fe(2+) + H(+) + NADP(+)
Reduction of Fe3+ in the endosome
output[SimpleEntity:917810] Fe2+ [endosome lumen]
[SimpleEntity:74722] H+ [endosome lumen]
[SimpleEntity:9861421] NADP+ [endosome lumen]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2010-12-14
reviewed[InstanceEdit:994085] D'Eustachio, P, 2010-11-05
reviewStatus[ReviewStatus:9821385] four stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1104075] R-HSA-917811.3
structureModified[InstanceEdit:9861414] Stephan, Ralf, 2024-02-20
summation[Summation:917796] The iron ions that are no longer bound to transferrin are re...
(hasEvent)[Pathway:917977] Transferrin endocytosis and recycling [Homo sapiens]
(precedingEvent)[Reaction:917936] MCOLN1 transports Fe2+ from endosome lumen to cytosol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9864286] Update Tracker - [Reaction:917811] STEAP3,STEAP4 reduce Fe3+ to Fe2+ - v88:[addLiteratureReference, addOutput, add_removeInput, modifyText]
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No pathways have been reviewed or authored by STEAP3,STEAP4 reduce Fe3+ to Fe2+ (917811)
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