Reactome: A Curated Pathway Database
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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person ESCRT Disassembly

Class:IdReaction:917693
_displayNameESCRT Disassembly
_doReleaseTRUE
_timestamp2011-03-02 09:08:32
authored[InstanceEdit:933345] Gillespie, ME, 2010-08-10
catalystActivity[CatalystActivity:917728] ATP hydrolysis activity of Vps/Vta1 [cytosol]
compartment[Compartment:74700] endosome membrane
created[InstanceEdit:917715] Gillespie, ME, 2010-07-29
edited[InstanceEdit:933345] Gillespie, ME, 2010-08-10
input[SimpleEntity:113592] ATP [cytosol]
[Complex:917699] ESCRT-III/Cargo Complex [endosome membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:933367] ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles
[LiteratureReference:933353] Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking
modified[InstanceEdit:933345] Gillespie, ME, 2010-08-10
[InstanceEdit:933391] Gillespie, ME, 2010-08-11
[InstanceEdit:933392] Gillespie, ME, 2010-08-11
[InstanceEdit:933395] Garapati, P V, 2010-08-11
[InstanceEdit:941859] Gillespie, ME, 2010-09-06
[InstanceEdit:1168660] Gillespie, ME, 2011-01-05
[InstanceEdit:1181401] Gillespie, ME, 2011-02-08
[InstanceEdit:1214652] Gillespie, ME, 2011-02-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameESCRT Disassembly
output[SimpleEntity:29370] ADP [cytosol]
[DefinedSet:917705] CHMP2 [cytosol] [Homo sapiens]
[DefinedSet:917714] CHMP4 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:917736] CHMP6 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:917703] CHMP7 [cytosol] [Homo sapiens]
[SimpleEntity:29372] Pi [cytosol]
[Complex:917712] Ubiquinated and PIP3 Endosmal Membrane Bound Cargo [endocytic vesicle membrane] [Homo sapiens]
[EntityWithAccessionedSequence:917722] CHMP3 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2011-03-15
reviewed[InstanceEdit:165091] Rush, MG, 2008-01-11 00:00:00
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1224945] R-HSA-917693.2
summation[Summation:933385] Disassembly Phase
The AAA-ATPase, Vps4 disassembles ESC...
(hasEvent)[Pathway:917729] Endosomal Sorting Complex Required For Transport (ESCRT) [Homo sapiens]
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No pathways have been reviewed or authored by ESCRT Disassembly (917693)