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Details on Person PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA

Class:Id	Reaction:916855
_displayName	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA
_doRelease	TRUE
_timestamp	2019-07-15 15:58:17
authored	[InstanceEdit:888605] Mahajan, SS, 2010-06-29
catalystActivity	[CatalystActivity:916852] 4-aminobutyrate:2-oxoglutarate transaminase activity of PXLP-K357-ABAT dimer:2Fe-2S [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:916854] Mahajan, SS, 2010-07-29
edited	[InstanceEdit:918271] Mahajan, SS, 2010-08-03
input	[SimpleEntity:916850] GABA [mitochondrial matrix] [SimpleEntity:113594] 2OG [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:916843] Primary structure and tissue distribution of human 4-aminobutyrate aminotransferase
modified	[InstanceEdit:917754] Mahajan, SS, 2010-07-30 [InstanceEdit:918281] Mahajan, SS, 2010-08-03 [InstanceEdit:936531] Mahajan, SS, 2010-08-23 [InstanceEdit:937323] Mahajan, SS, 2010-08-26 [InstanceEdit:9644714] D'Eustachio, Peter, 2019-04-17 [InstanceEdit:9644851] Jassal, Bijay, 2019-04-25 [InstanceEdit:9653175] D'Eustachio, Peter, 2019-07-10 [InstanceEdit:9653792] D'Eustachio, Peter, 2019-07-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA Conversion of GABA to Succinate Semialdehyde
output	[SimpleEntity:113552] L-Glu [mitochondrial matrix] [SimpleEntity:880046] SUCCSA [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:9653180] GABA translocates from cytosol to mitochondrial matrix [Homo sapiens] [Reaction:444007] GAT1-3 mediate Na+/Cl- dependent GABA transport [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49 [InstanceEdit:9653791] Jassal, Bijay, 2019-07-15
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9653175] D'Eustachio, Peter, 2019-07-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104710] R-HSA-916855.4
summation	[Summation:917746] GABA and 2-oxoglutarate (2OG) are converted to succinate sem...
(hasEvent)	[Pathway:916853] Degradation of GABA [Homo sapiens]
(precedingEvent)	[Reaction:880002] (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate [Homo sapiens] [Reaction:888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777627] Update Tracker - [Reaction:916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - v70:[modifyText] [_UpdateTracker:9777804] Update Tracker - [Reaction:916855] PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA - v69:[removeInput, removeOutput]
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