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Details on Person UniProt:P16371 gro
| Class:Id | ReferenceGeneProduct:91660 |
|---|---|
| _chainChangeLog | chain:1-730 added on Fri February 6 2015 |
| _displayName | UniProt:P16371 gro |
| _timestamp | 2024-08-09 19:11:35 |
| chain | chain:1-730 |
| checksum | 9DA08E1ED343B2F5 |
| comment | FUNCTION Transcriptional corepressor that regulates transcription when recruited to specific target DNA by hairy-related bHLH proteins (PubMed:8001118, PubMed:8649374). Maternally required for neurogenesis; in the segregation of the neuroectoderm (PubMed:8001118). Directly or indirectly interacts with Notch and Delta (PubMed:8001118).SUBUNIT Forms a complex with the hairy/Enhancer of split/deadpan family of basic helix-loop-helix proteins in order to repress transcription (PubMed:8001118, PubMed:8649374). Its activity in regulating transcription depends on other proteins as it lacks a DNA-binding motif (PubMed:8001118, PubMed:8649374). Interacts with hairy/hry (via WRPW motif) (PubMed:8649374).INTERACTION Expressed both maternally and zygotically.PTM Ubiquitinated by XIAP/BIRC4 (PubMed:22304967). Ubiquitinated by hyd in response to Wnt signaling, leading to degradation by the proteasome (PubMed:28689657).SIMILARITY Belongs to the WD repeat Groucho/TLE family. |
| description | recommendedName: Protein groucho alternativeName: Enhancer of split m9/10 protein shortName: E(spl)m9/10 |
| geneName | gro E(spl)m9/m10 CG8384 |
| identifier | P16371 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Developmental protein Differentiation Neurogenesis Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation WD repeat Wnt signaling pathway |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | gro |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GROU_DROME A4V3F6 Q0KI08 Q7KRZ4 Q9V3F7 |
| sequenceLength | 730 |
| species | [Species:56210] Drosophila melanogaster |
| (isoformParent) | [ReferenceIsoform:231213] UniProt:P16371-2 gro [Drosophila melanogaster] [ReferenceIsoform:403041] UniProt:P16371-1 gro [Drosophila melanogaster] |
| (referenceEntity) | [EntityWithAccessionedSequence:205750] GRO [nucleoplasm] [Drosophila melanogaster] |
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No pathways have been reviewed or authored by UniProt:P16371 gro (91660)
