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Details on Person B3GNT6 transfers GlcNAc to Tn antigen

Class:Id	Reaction:914010
_displayName	B3GNT6 transfers GlcNAc to Tn antigen
_doRelease	TRUE
_timestamp	2025-04-08 08:39:30
authored	[InstanceEdit:913626] Jassal, B, 2010-07-19
catalystActivity	[CatalystActivity:916826] acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity of B3GNTs [Golgi membrane]
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:914014] Jassal, B, 2010-07-21
crossReference	[DatabaseIdentifier:9942398] RHEA:46881 [DatabaseIdentifier:9942405] RHEA:46885
edited	[InstanceEdit:913626] Jassal, B, 2010-07-19
input	[DefinedSet:913659] Tn antigens [Golgi lumen] [Homo sapiens] [SimpleEntity:914003] UDP-GlcNAc [Golgi lumen]
isChimeric	FALSE
literatureReference	[LiteratureReference:977027] Comprehensive enzymatic characterization of glycosyltransferases with a beta3GT or beta4GT motif [LiteratureReference:977055] Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains [LiteratureReference:977036] Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family [LiteratureReference:977049] Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids [LiteratureReference:977054] Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans [LiteratureReference:977048] Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family [LiteratureReference:977038] A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer [LiteratureReference:977061] Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase [LiteratureReference:9942400] Synthesis of O-glycan core 3: characterization of UDP-GlcNAc: GalNAc-R beta 3-N-acetyl-glucosaminyltransferase activity from colonic mucosal tissues and lack of the activity in human cancer cell lines
modified	[InstanceEdit:916825] Jassal, B, 2010-07-28 [InstanceEdit:976828] Jassal, B, 2010-10-14 [InstanceEdit:977010] Jassal, B, 2010-10-14 [InstanceEdit:977057] Jassal, B, 2010-10-14 [InstanceEdit:981828] Jassal, B, 2010-10-27 [InstanceEdit:981846] Jassal, B, 2010-10-28 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1462326] Wu, G, 2011-07-28 [InstanceEdit:1963546] Jassal, B, 2011-11-03 [InstanceEdit:1963553] Jassal, B, 2011-11-03 [InstanceEdit:1964511] Jassal, B, 2011-11-04 [InstanceEdit:1965758] Jassal, B, 2011-11-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9942394] Stephan, Ralf, 2025-03-16 [InstanceEdit:9944934] Stephan, Ralf, 2025-04-08
name	B3GNT6 transfers GlcNAc to Tn antigen Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein
output	[DefinedSet:1462159] Core 3 mucins [Golgi lumen] [Homo sapiens] [SimpleEntity:205687] UDP [Golgi lumen] [SimpleEntity:425969] H+ [Golgi lumen]
precedingEvent	[Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2011-12-06
reviewed	[InstanceEdit:1964508] Ferrer, A, 2011-11-04 [InstanceEdit:9944933] D'Eustachio, Peter, 2025-04-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016566] R-HSA-914010.3
structureModified	[InstanceEdit:9942394] Stephan, Ralf, 2025-03-16
summation	[Summation:976997] Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acet...
(hasEvent)	[Pathway:913709] O-linked glycosylation of mucins [Homo sapiens]
(precedingEvent)	[Reaction:914018] GCNT3 transfers GlcNAc to Core 3 mucin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9953698] Update Tracker - [Reaction:914010] B3GNT6 transfers GlcNAc to Tn antigen - v93:[modifyText, removeLiteratureReference, removeOutput]
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