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Details on Person UniProt:P19490 Gria1
| Class:Id | ReferenceGeneProduct:91400 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 6 2015;chain:19-907 added on Fri February 6 2015 |
| _displayName | UniProt:P19490 Gria1 |
| _timestamp | 2024-08-09 18:43:16 |
| chain | signal peptide:1-18 chain:19-907 |
| checksum | 2D4CFA7CCD532838 |
| comment | FUNCTION Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:2166337, PubMed:2168579). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium (PubMed:11773314, PubMed:18817736). The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist (PubMed:16793768, PubMed:19265014). In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (PubMed:16793768, PubMed:19265014). Resensitization is blocked by CNIH2 through interaction with CACNG8 in the CACNG8-containing AMPA receptors complex (By similarity). Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable (PubMed:1709304). Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (PubMed:11773314).CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY Mg(2+)(in) = Mg(2+)(out)CATALYTIC ACTIVITY Li(+)(in) = Li(+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)CATALYTIC ACTIVITY Sr(2+)(in) = Sr(2+)(out)ACTIVITY REGULATION Glutamate-gated receptor activity inhibited by DNQX (6,7-dinitroquinoxaline-2,3-dione).SUBUNIT Homotetramer or heterotetramer of pore-forming glutamate receptor subunits; heteromeric assembly can be the result of both receptor subtype and flip-flop forms and according the composition, one partner can be dominant with respect to the fast desensitizing current component, whereas the other can determine the steady-state component (PubMed:1699275, PubMed:21639859, PubMed:2168579). Tetramers may be formed by the dimerization of dimers (By similarity). Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8 (PubMed:19265014). Interacts with HIP1 and RASGRF2. Interacts with SYNDIG1 and GRIA2 (By similarity). Interacts with DLG1 (via C-terminus) (PubMed:12070168, PubMed:17069616, PubMed:9677374). Interacts with LRFN1 (PubMed:16630835). Interacts with PRKG2 (PubMed:18031684). Interacts with CNIH2 and CACNG2 (PubMed:20805473). Interacts with CACNG5; this interaction modulates the gating (PubMed:18817736, PubMed:19234459). Interacts (via C-terminus) with PDLIM4 (via LIM domain); this interaction as well as the interaction of PDLIM4 with alpha-actinin is required for their colocalization in early endosomes (PubMed:15456832). Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain) (By similarity). Interacts with CACNG3; associates GRIA1 with the adapter protein complex 4 (AP-4) to target GRIA1 to the somatodendritic compartment of neurons (By similarity). Interacts with CACNG2; this interaction mediates traffick to the plasma membrane and modulation of desensitization (PubMed:16793768). Interaction with CNIH2 and CNIH3; this interaction promotes expression at the plasma membrane and extensively modulates their gating properties by slowing deactivation and desensitization kinetics (PubMed:19265014). Found in a complex with GRIA2, GRIA3, GRIA4, DLG4, CACNG8 and CNIH2 (By similarity).INTERACTION Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (PubMed:19265014). Colocalizes with PDLIM4 in early endosomes (PubMed:15456832). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). Localized to cone photoreceptor pedicles (By similarity).ALTERNATIVE PRODUCTS Detected in cerebellum (at protein level).DOMAIN The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.PTM Phosphorylated at Ser-645 (PubMed:7877986). Phosphorylated at Ser-710 by PKC (PubMed:8848293). Phosphorylated at Ser-849 by PKC, PKA and CAMK2 (PubMed:9405465). Phosphorylated at Ser-863 by PKC, PKA and PRKG2 (PubMed:18031684, PubMed:9405465). Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (By similarity).PTM Palmitoylated. Depalmitoylated by CPT1C and upon L-glutamate stimulation. ZDHHC3/GODZ specifically palmitoylates Cys-603, which leads to Golgi retention and decreased cell surface expression (By similarity). In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).POLYMORPHISM Both variants Ser-710 and Thr-710 are phosphorylated at this position.MISCELLANEOUS The postsynaptic actions of L-glutamate are mediated by a variety of receptors that are named according to their selective agonists (Probable). This receptor binds AMPA (quisqualate) > L-glutamate > kainate (Probable).SIMILARITY Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily. |
| description | recommendedName: fullName evidence="32"Glutamate receptor 1 shortName: GluR-1 alternativeName: AMPA-selective glutamate receptor 1 alternativeName: fullName evidence="29"GluR-A alternativeName: fullName evidence="31"GluR-K1 alternativeName: Glutamate receptor ionotropic, AMPA 1 |
| geneName | Gria1 GluA1 Glur1 |
| identifier | P19490 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Cell projection Disulfide bond Endoplasmic reticulum Endosome Glycoprotein Ion channel Ion transport Ligand-gated ion channel Lipoprotein Membrane Palmitate Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Gria1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GRIA1_RAT |
| sequenceLength | 907 |
| species | [Species:48895] Rattus norvegicus |
| (isoformParent) | [ReferenceIsoform:148010] UniProt:P19490-2 Gria1 [Rattus norvegicus] [ReferenceIsoform:403192] UniProt:P19490-1 Gria1 [Rattus norvegicus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9620440] Gria1 [plasma membrane] [Rattus norvegicus] [EntityWithAccessionedSequence:9620442] p-S849-Gria1 [plasma membrane] [Rattus norvegicus] |
| (referenceSequence) | [ModifiedResidue:9620438] O-phospho-L-serine at 849 |
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No pathways have been reviewed or authored by UniProt:P19490 Gria1 (91400)
