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Details on Person viral dsRNA binds IFIH1:TKFC

Class:Id	Reaction:913725
_displayName	viral dsRNA binds IFIH1:TKFC
_doRelease	TRUE
_timestamp	2023-05-18 15:10:10
authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:913723] Garapati, P V, 2010-07-19
edited	[InstanceEdit:918228] Garapati, P V, 2010-08-02
input	[DefinedSet:9038422] IFIH1 ligand [cytosol] [Measles virus] [Complex:918203] IFIH1:TKFC [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:913728] Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5 [LiteratureReference:918206] Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase [LiteratureReference:936495] Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5
modified	[InstanceEdit:913729] Garapati, P V, 2010-07-19 [InstanceEdit:918223] Garapati, P V, 2010-08-02 [InstanceEdit:936502] Garapati, P V, 2010-08-23 [InstanceEdit:990524] Garapati, P V, 2010-11-03 [InstanceEdit:994081] Garapati, P V, 2010-11-05 [InstanceEdit:998145] Garapati, P V, 2010-11-09 [InstanceEdit:1022090] Garapati, P V, 2010-11-17 [InstanceEdit:6790582] Shamovsky, Veronica, 2015-08-13 [InstanceEdit:8983918] Jupe, Steve, 2017-03-31 [InstanceEdit:9013955] Shamovsky, Veronica, 2017-07-26 [InstanceEdit:9014388] Shamovsky, Veronica, 2017-07-28 [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9038421] Shamovsky, Veronica, 2018-02-26 [InstanceEdit:9717699] Shamovsky, Veronica, 2021-03-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9835853] Shamovsky, Veronica, 2023-05-18
name	viral dsRNA binds IFIH1:TKFC viral dsRNA binds IFIH1:DAK dsRNA binds to MDA5
output	[EntityWithAccessionedSequence:918185] TKFC [cytosol] [Homo sapiens] [Complex:913727] viral dsRNA:IFIH1 [cytosol] [Homo sapiens]
relatedSpecies	[Species:9013948] Measles virus [Species:9031716] Influenza A virus [Species:9717528] Human respiratory syncytial virus A
releaseDate	2010-12-14
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104995] R-HSA-913725.7
summation	[Summation:913724] Interferon-induced helicase C domain-containing protein 1 (I...
(hasEvent)	[Pathway:168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta [Homo sapiens]
(inferredFrom)	[Reaction:1227694] dsRNA binds to MDA5 [Gallus gallus]
(precedingEvent)	[Reaction:168909] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS [Homo sapiens] [Reaction:9733943] YWHAH binds IFIH1 [Homo sapiens] [Reaction:9833393] N interacts with IFIH1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776242] Update Tracker - [Reaction:913725] viral dsRNA binds IFIH1:TKFC - v77:[modifyText] [_UpdateTracker:9780078] Update Tracker - [Reaction:913725] viral dsRNA binds IFIH1:TKFC - v64:[add_removeInput] [_UpdateTracker:9780651] Update Tracker - [Reaction:913725] viral dsRNA binds IFIH1:TKFC - v62:[add_removeInput] [_UpdateTracker:9781396] Update Tracker - [Reaction:913725] viral dsRNA binds IFIH1:TKFC - v61:[modifyText] [_UpdateTracker:9784439] Update Tracker - [Reaction:913725] viral dsRNA binds IFIH1:TKFC - v54:[add_removeInput]
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No pathways have been reviewed or authored by viral dsRNA binds IFIH1:TKFC (913725)