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Details on Person GALNTs transfer GalNAc to Mucins to form Tn antigens

Class:IdReaction:913675
_displayNameGALNTs transfer GalNAc to Mucins to form Tn antigens
_doReleaseTRUE
_timestamp2025-04-08 08:41:15
authored[InstanceEdit:913626] Jassal, B, 2010-07-19
catalystActivity[CatalystActivity:913697] polypeptide N-acetylgalactosaminyltransferase activity of GALNTs [Golgi membrane]
compartment[Compartment:20699] Golgi membrane
[Compartment:17963] Golgi lumen
created[InstanceEdit:913626] Jassal, B, 2010-07-19
crossReference[DatabaseIdentifier:9942380] RHEA:23957
[DatabaseIdentifier:9942378] RHEA:52425
edited[InstanceEdit:913626] Jassal, B, 2010-07-19
input[DefinedSet:913666] Mucins [Golgi lumen] [Homo sapiens]
[SimpleEntity:9942384] UDP-GalNAc [Golgi lumen]
isChimericFALSE
literatureReference[LiteratureReference:976842] Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3
[LiteratureReference:977014] Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus
[LiteratureReference:8849565] Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family
modified[InstanceEdit:913719] Jassal, B, 2010-07-19
[InstanceEdit:914014] Jassal, B, 2010-07-21
[InstanceEdit:976828] Jassal, B, 2010-10-14
[InstanceEdit:977010] Jassal, B, 2010-10-14
[InstanceEdit:981828] Jassal, B, 2010-10-27
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1963546] Jassal, B, 2011-11-03
[InstanceEdit:1963553] Jassal, B, 2011-11-03
[InstanceEdit:1964511] Jassal, B, 2011-11-04
[InstanceEdit:1965758] Jassal, B, 2011-11-04
[InstanceEdit:6785549] Jassal, Bijay, 2015-06-29
[InstanceEdit:8849581] Jassal, Bijay, 2015-12-16
[InstanceEdit:8851015] Jassal, Bijay, 2016-01-05
[InstanceEdit:9756078] Jassal, Bijay, 2021-10-12
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9942382] Stephan, Ralf, 2025-03-15
[InstanceEdit:9944934] Stephan, Ralf, 2025-04-08
nameGALNTs transfer GalNAc to Mucins to form Tn antigens
Addition of GalNAc to mucins to form the Tn antigen
output[DefinedSet:913659] Tn antigens [Golgi lumen] [Homo sapiens]
[SimpleEntity:205687] UDP [Golgi lumen]
[SimpleEntity:425969] H+ [Golgi lumen]
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2011-12-06
reviewed[InstanceEdit:1964508] Ferrer, A, 2011-11-04
[InstanceEdit:9944933] D'Eustachio, Peter, 2025-04-08
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2016152] R-HSA-913675.6
structureModified[InstanceEdit:9942382] Stephan, Ralf, 2025-03-15
summation[Summation:976826] The family of UDP GalNAc:polypeptide N acetylgalactosaminylt...
(hasEvent)[Pathway:913709] O-linked glycosylation of mucins [Homo sapiens]
(normalReaction)[FailedReaction:5096532] Defective GALNT12 does not transfer GalNAc to mucins [Homo sapiens]
[FailedReaction:5096537] Defective GALNT3 does not transfer GalNAc to mucins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:914005] Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein [Homo sapiens]
[BlackBoxEvent:914006] Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein [Homo sapiens]
[BlackBoxEvent:914008] Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein [Homo sapiens]
[Reaction:914010] B3GNT6 transfers GlcNAc to Tn antigen [Homo sapiens]
[BlackBoxEvent:914017] Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein [Homo sapiens]
[Reaction:977071] ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens [Homo sapiens]
[Reaction:1964505] C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775469] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v79:[modifyText]
[_UpdateTracker:9783512] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v56:[add_removeLiteratureReference, modifyText]
[_UpdateTracker:9786842] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v47:[modifyText]
[_UpdateTracker:9953576] Update Tracker - [Reaction:913675] GALNTs transfer GalNAc to Mucins to form Tn antigens - v93:[add_removeInput, removeOutput]
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