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Details on Person Cleavage of GP1BA and GPV ectodomains by ADAM17

Class:Id	Reaction:913590
_displayName	Cleavage of GP1BA and GPV ectodomains by ADAM17
_timestamp	2023-11-17 05:14:58
catalystActivity	[CatalystActivity:913561] metallopeptidase activity of ADAM17, (ADAM10) [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:913544] Jupe, S, 2010-07-19
input	[Complex:114668] GPIb-IX-V [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:913542] Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo [LiteratureReference:913571] Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V [LiteratureReference:913559] Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases
modified	[InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:9853542] Shamovsky, Veronica, 2023-11-17
name	Cleavage of GP1BA and GPV ectodomains by ADAM17
output	[Complex:913569] GP1BA(507-652):GP1BB:GP9:GP5(510-560) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:913601] GP1BA(17-506) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:913596] GP5(17-509) [extracellular region] [Homo sapiens]
stableIdentifier	[StableIdentifier:8886136] R-NUL-913590.1
summation	[Summation:913587] Expression and function of the GP1BA:GP1BB:GP9:GP5 (GP1B-IX-...
(hasEvent)	[Pathway:430116] GP1b-IX-V activation signalling [Homo sapiens]
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