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Details on Person Expression and function of the GP1BA:GP1BB:GP9:GP5 (GP1B-IX-...
| Class:Id | Summation:913587 |
|---|---|
| _displayName | Expression and function of the GP1BA:GP1BB:GP9:GP5 (GP1B-IX-... |
| _timestamp | 2023-11-21 10:35:25 |
| created | [InstanceEdit:913544] Jupe, S, 2010-07-19 |
| literatureReference | [LiteratureReference:913572] Glycoprotein Ib-IX-V [LiteratureReference:913577] [alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients [LiteratureReference:913559] Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases [LiteratureReference:9853869] Mechanisms of receptor shedding in platelets [LiteratureReference:9853875] Platelet Membrane Receptor Proteolysis: Implications for Platelet Function [LiteratureReference:913571] Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V [LiteratureReference:913542] Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo |
| modified | [InstanceEdit:9853543] Shamovsky, Veronica, 2023-11-17 [InstanceEdit:9853871] Shamovsky, Veronica, 2023-11-21 |
| text | Expression and function of the GP1BA:GP1BB:GP9:GP5 (GP1B-IX-V) complex is regulated by shedding of receptor ectodomains from the platelet surface (reviewed in Montague SJ et al., 2018; Wu J et al., 2020). The ectodomain of GP1BA (GP1B subunit α) is continuously cleaved by a disintegrin and metalloproteinase 17 (ADAM17, also known as tumor necrosis factor-alpha converting enzyme TACE) (Andrews RK et al., 2003; Bergmeier W et al., 2004; Gardiner EE et al., 2007). The cleavage site is located within the mechanosensory domain of GP1BA. The ADAM17-mediated cleavage of GP1BA releases a fragment known as glycocalicin (GP1BA(17-506)) (Andrews RK et al., 2003; Gardiner EE et al., 2007). Similarly, the ectodomain of GP5 (GPV) is cleaved releasing GP5 ectodomain (Rabie T et al., 2005; Gardiner EE et al., 2007). ADAM17 is the most important protease involved though other proteases such as ADAM10 may play a role (ColciaghiF et al., 2002, Gardiner EE et al., 2007). |
| (summation) | [Reaction:913590] Cleavage of GP1BA and GPV ectodomains by ADAM17 |
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No pathways have been reviewed or authored by Expression and function of the GP1BA:GP1BB:GP9:GP5 (GP1B-IX-... (913587)
