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Details on Person IL3RB is phosphorylated on Ser-585

Class:Id	Reaction:913451
_displayName	IL3RB is phosphorylated on Ser-585
_doRelease	TRUE
_timestamp	2011-09-09 08:56:01
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:914181] cAMP-dependent protein kinase activity of PRKACA [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:913398] Jupe, S, 2010-07-14
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
input	[DefinedSet:913399] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:913396] Identification of a 14-3-3 binding sequence in the common beta chain of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors that is serine-phosphorylated by GM-CSF [LiteratureReference:914172] Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival
modified	[InstanceEdit:914176] Jupe, S, 2010-07-23 [InstanceEdit:927713] Jupe, S, 2010-08-06 [InstanceEdit:941871] Jupe, S, 2010-09-06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1474064] Jupe, S, 2011-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IL3RB is phosphorylated on Ser-585
output	[DefinedSet:914179] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:879942] The receptor is activated [Homo sapiens] [Reaction:450031] Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 [Homo sapiens] [Reaction:913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 [Homo sapiens] [Reaction:913371] GM-CSF receptor alpha:GM-CSF binds Bc [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104944] R-HSA-913451.2
summation	[Summation:913419] GM-CSF and IL-3 application lead to Ser-585 phosphorylation ...
(hasEvent)	[Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Homo sapiens]
(precedingEvent)	[Reaction:912757] p-S585-IL3RB binds 14-3-3 proteins [Homo sapiens]
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No pathways have been reviewed or authored by IL3RB is phosphorylated on Ser-585 (913451)