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Details on Person Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

Class:Id	Reaction:913370
_displayName	Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
_doRelease	TRUE
_timestamp	2011-09-09 08:58:23
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:913398] Jupe, S, 2010-07-14
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
input	[Complex:450056] IL5 homodimer:IL5RA [plasma membrane] [Homo sapiens] [Complex:879945] IL3RB:JAK2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:450067] A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF [LiteratureReference:914208] Molecular basis of a high affinity murine interleukin-5 receptor
modified	[InstanceEdit:914195] Jupe, S, 2010-07-23 [InstanceEdit:927713] Jupe, S, 2010-08-06 [InstanceEdit:941868] Jupe, S, 2010-09-06 [InstanceEdit:1474064] Jupe, S, 2011-08-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
output	[Complex:913423] IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:913456] Interleukin-5 receptor alpha subunit binds Interleukin-5 [Homo sapiens] [Reaction:913446] Interleukin-5 is a homodimer [Homo sapiens] [Reaction:879937] The common beta chain IL3RB binds JAK2 [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104400] R-HSA-913370.2
summation	[Summation:914202] The alpha subunit of the IL5 receptor binds IL-5 with relati...
(hasEvent)	[Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Homo sapiens]
(precedingEvent)	[Reaction:879907] Tyrosine kinases phosphorylate the receptor [Homo sapiens] [BlackBoxEvent:879942] The receptor is activated [Homo sapiens]
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No pathways have been reviewed or authored by Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (913370)