Query author contributions in Reactome
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Details on Person CBL phosphorylation at Y731 is postulated to provide an addi...
| Class:Id | Summation:912562 |
|---|---|
| _displayName | CBL phosphorylation at Y731 is postulated to provide an addi... |
| _timestamp | 2010-07-12 17:24:35 |
| created | [InstanceEdit:912563] Jupe, S, 2010-07-09 |
| literatureReference | [LiteratureReference:912558] Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase |
| modified | [InstanceEdit:912661] Jupe, S, 2010-07-12 |
| text | CBL phosphorylation at Y731 is postulated to provide an additional interaction between CBL and the SH2 domain of p85. This is supported by increased CBL-p85 association observed in activated cells (Panchamoorthy et al 1996). CBL-p85 binding negatively regulates PI3K activity (Fang et al. 2001); CBL phosphorylation at Y731 increased PI3K ubiquitination and proteasome degradation (Dufour et al. 2008). |
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No pathways have been reviewed or authored by CBL phosphorylation at Y731 is postulated to provide an addi... (912562)
