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Details on Person SHC1 mediates cytokine-induced phosphorylation of GAB2

Class:Id	BlackBoxEvent:912527
_displayName	SHC1 mediates cytokine-induced phosphorylation of GAB2
_doRelease	TRUE
_timestamp	2011-06-02 11:30:48
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:912521] Jupe, S, 2010-07-09
edited	[InstanceEdit:924611] Jupe, S, 2010-08-06
input	[DefinedSet:912537] Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:507990] Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a [LiteratureReference:507926] New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
modified	[InstanceEdit:912541] Jupe, S, 2010-07-09 [InstanceEdit:918253] Jupe, S, 2010-08-02 [InstanceEdit:919403] Jupe, S, 2010-08-04 [InstanceEdit:926765] Jupe, S, 2010-08-06 [InstanceEdit:941871] Jupe, S, 2010-09-06 [InstanceEdit:975849] Jupe, S, 2010-10-05 [InstanceEdit:1233244] Jupe, S, 2011-03-17 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SHC1 mediates cytokine-induced phosphorylation of GAB2
output	[DefinedSet:912533] Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:453104] Phosphorylated SHC1 recruits GRB2:GAB2 [Homo sapiens] [Reaction:452100] SHC1 bound to IL2 receptor is phosphorylated [Homo sapiens] [Reaction:879925] SHC1 bound to the common beta chain becomes tyrosine phosphorylated [Homo sapiens] [Reaction:183052] CBL binds to GRB2 [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:1213492] Villarino, A, 2011-02-11 [InstanceEdit:1233246] Dooms, H, 2011-03-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104426] R-HSA-912527.2
summation	[Summation:912524] Binding of Gab2 to tyrosine phosphorylated Shc promotes the ...
(hasEvent)	[Pathway:912526] Interleukin receptor SHC signaling [Homo sapiens]
(precedingEvent)	[Reaction:508247] Gab2 binds the p85 subunit of Class 1A PI3 kinases [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790113] Update Tracker - [BlackBoxEvent:912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - v35:[modifyText, removeCatalystActivity]
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