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Details on Person GRB2:GAB2 [cytosol]
Class:Id Complex:912522
_displayName GRB2:GAB2 [cytosol]
_timestamp 2020-03-27 08:29:34
compartment [Compartment:70101] cytosol
created [InstanceEdit:912521] Jupe, S, 2010-07-09
hasComponent
isChimeric FALSE
literatureReference [LiteratureReference:508010] Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2
modified [InstanceEdit:9680383] May, Bruce, 2020-03-27
name GRB2:GAB2
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:1108724] R-HSA-912522.2
(hasComponent) [Complex:508246] IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] [Homo sapiens] [Complex:912538] IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] [Homo sapiens] [Complex:914021] High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] [Homo sapiens] [Complex:914047] High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] [Homo sapiens] [Complex:1839045] pY177-BCR1-p-FGFR1 mutant:GRB2:GAB2 [cytosol] [Homo sapiens]
(input) [BlackBoxEvent:453104] Phosphorylated SHC1 recruits GRB2:GAB2 [Homo sapiens] [Reaction:1839095] p-BCR-pFGFR1 binds GRB2:GAB2 [Homo sapiens] [BlackBoxEvent:9680348] PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated [Homo sapiens]
(updatedInstance) [_UpdateTracker:9901274] Update Tracker - [Complex:912522] GRB2:GAB2 [cytosol] - v73:[addLiteratureReference]
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No pathways have been reviewed or authored by GRB2:GAB2 [cytosol] (912522)