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Details on Person MLH1 [nucleoplasm]

Class:Id	EntityWithAccessionedSequence:912495
_displayName	MLH1 [nucleoplasm]
_timestamp	2025-09-29 21:43:37
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:912491] May, B, 2010-07-08
endCoordinate	756
modified	[InstanceEdit:3448660] Wu, G, 2013-05-16 [InstanceEdit:3632907] Wu, G, 2013-05-28 [InstanceEdit:9967511] D'Eustachio, Peter, 2025-09-29
name	MLH1 DNA mismatch repair protein Mlh1 MLH1_HUMAN
referenceEntity	[ReferenceGeneProduct:59369] UniProt:P40692 MLH1 [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1225434] R-HSA-912495.2
startCoordinate	2
(hasComponent)	[Complex:914134] MLH1:MLH3 [nucleoplasm] [Homo sapiens] [Complex:5357522] MLH1:PMS2 [nucleoplasm] [Homo sapiens] [Complex:5357526] MLH1:PMS1 [nucleoplasm] [Homo sapiens]
(input)	[BlackBoxEvent:912429] Resolution of meiotic holliday junction [Homo sapiens] [Reaction:5444523] Formation of MSH1:PMS2 Complex [Homo sapiens] [FailedReaction:5632958] PMS2 variants-defective DNA mismatch repair [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:5545475] loss_of_function of MLH1 Variants [nucleoplasm]
(output)	[BlackBoxEvent:6806392] TP53 stimulates MLH1 expression [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9972633] Update Tracker - [EntityWithAccessionedSequence:912495] MLH1 [nucleoplasm] - v95:[modifyStartCoordinate]
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No pathways have been reviewed or authored by MLH1 [nucleoplasm] (912495)