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Details on Person ATR phosphorylates Histone H2A.X at unsynapsed regions

Class:Id	Reaction:912470
_displayName	ATR phosphorylates Histone H2A.X at unsynapsed regions
_doRelease	TRUE
_timestamp	2014-02-06 18:09:33
authored	[InstanceEdit:913923] May, B, 2010-07-19
catalystActivity	[CatalystActivity:912432] protein serine/threonine kinase activity of Synaptonemal Complex:BRCA1:ATR [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:912491] May, B, 2010-07-08
edited	[InstanceEdit:913923] May, B, 2010-07-19
inferredFrom	[Reaction:912423] Atr Phosphorylates Histone H2A.X at Unsynapsed Regions [Mus musculus]
input	[Complex:975778] Unsynapsed chromatin [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:912457] ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes [LiteratureReference:913816] Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
modified	[InstanceEdit:913736] May, B, 2010-07-19 [InstanceEdit:914114] May, B, 2010-07-22 [InstanceEdit:975788] May, B, 2010-10-04 [InstanceEdit:975851] May, B, 2010-10-06 [InstanceEdit:1008999] May, B, 2010-11-11 [InstanceEdit:1086964] May, B, 2010-11-29 [InstanceEdit:1220550] May, B, 2011-02-20 [InstanceEdit:1221624] May, B, 2011-02-25 [InstanceEdit:1296160] May, B, 2011-05-19 [InstanceEdit:5255525] May, B, 2014-02-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ATR phosphorylates Histone H2A.X at unsynapsed regions
output	[Complex:975781] Unsynapsed chromatin with gamma-H2A.x [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:912450] ATR Kinase is recruited to unsynapsed regions [Homo sapiens] [Reaction:912467] BRCA1 is recruited to unsynapsed regions [Homo sapiens]
releaseDate	2011-06-14
reviewed	[InstanceEdit:1221628] Bolcun-Filas, E, 2011-02-25 [InstanceEdit:1181360] Cohen, PE, 2011-02-04 [InstanceEdit:1181371] Holloway, JK, 2011-02-04 [InstanceEdit:1221625] Lyndaker, A, 2011-02-25 [InstanceEdit:1181380] Schimenti, JC, 2011-02-04 [InstanceEdit:1221623] Strong, E, 2011-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1357636] R-HSA-912470.2
summation	[Summation:914120] The ATR kinase phosphorylates histone H2A.X at serine 139 (W...
(hasEvent)	[Pathway:1221632] Meiotic synapsis [Homo sapiens]
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