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Details on Person Atr Phosphorylates Histone H2A.X at Unsynapsed Regions

Class:Id	Reaction:912423
_displayName	Atr Phosphorylates Histone H2A.X at Unsynapsed Regions
_doRelease	TRUE
_timestamp	2011-06-10 08:40:48
authored	[InstanceEdit:912374] May, B, 2010-07-02
catalystActivity	[CatalystActivity:912485] protein serine/threonine kinase activity of Synaptonemal Complex:BRCA1:ATR [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:912491] May, B, 2010-07-08
edited	[InstanceEdit:912374] May, B, 2010-07-02
input	[Complex:975779] Unsynapsed chromatin [nucleoplasm] [Mus musculus] [SimpleEntity:29358] ATP [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:913874] BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation [LiteratureReference:913845] SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes [LiteratureReference:913855] Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation
modified	[InstanceEdit:913736] May, B, 2010-07-19 [InstanceEdit:914114] May, B, 2010-07-22 [InstanceEdit:975788] May, B, 2010-10-04 [InstanceEdit:975791] May, B, 2010-10-04 [InstanceEdit:975851] May, B, 2010-10-06 [InstanceEdit:1008999] May, B, 2010-11-11 [InstanceEdit:1086964] May, B, 2010-11-29 [InstanceEdit:1220550] May, B, 2011-02-20 [InstanceEdit:1221624] May, B, 2011-02-25 [InstanceEdit:1296160] May, B, 2011-05-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Atr Phosphorylates Histone H2A.X at Unsynapsed Regions
output	[Complex:975782] Unsynapsed chromatin with gamma-H2A.x [nucleoplasm] [Mus musculus] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:912449] Recruitment of Atr Kinase to Unsynapsed Regions [Mus musculus] [Reaction:912468] Recruitment of Brca1 to Unsynapsed Regions [Mus musculus]
releaseDate	2011-06-14
reviewed	[InstanceEdit:1221628] Bolcun-Filas, E, 2011-02-25 [InstanceEdit:1181360] Cohen, PE, 2011-02-04 [InstanceEdit:1181371] Holloway, JK, 2011-02-04 [InstanceEdit:1221625] Lyndaker, A, 2011-02-25 [InstanceEdit:1181380] Schimenti, JC, 2011-02-04 [InstanceEdit:1221623] Strong, E, 2011-02-25
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:1357491] R-MMU-912423.2
summation	[Summation:914139] The Atr kinase phosphorylates H2A.x at Serine 140 (Turner et...
(inferredFrom)	[Reaction:912470] ATR phosphorylates Histone H2A.X at unsynapsed regions [Homo sapiens]
(replacementInstances)	[_Deleted:9032440] Deletion of instance: 5334727 [_Deleted:9032448] Deletion of instance: 1221633
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