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Details on Person UniProt:Q8IWJ2 GCC2
| Class:Id | ReferenceGeneProduct:91143 |
|---|---|
| _chainChangeLog | chain:1-1684 added on Fri February 6 2015 |
| _displayName | UniProt:Q8IWJ2 GCC2 |
| _timestamp | 2024-11-03 19:45:54 |
| chain | chain:1-1684 |
| checksum | 83B6135D9EB9440D |
| comment | FUNCTION Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2.SUBUNIT Homodimer. Interacts (via GRIP domain) with RAB6A (preferentially in its GTP-bound form). May interact (RAB6A-dependent) with ARL1; according to PubMed:19703403, RAB6A and ARL1 are not involved in GCC2 Golgi localization as proposed by PubMed:18243103. Interacts (probably via GRIP domain) with RAB9A (preferentially in its GTP-bound form). Interacts with CLASP1 and CLASP2; recruits both proteins to membranes of the TGN. Interacts with STX16.INTERACTION Ubiquitous.DOMAIN Extended rod-like protein with coiled-coil domains.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.SEQUENCE CAUTION Wrong choice of CDS.SEQUENCE CAUTION Wrong choice of CDS.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Wrong choice of CDS. |
| description | recommendedName: GRIP and coiled-coil domain-containing protein 2 alternativeName: 185 kDa Golgi coiled-coil protein shortName: GCC185 alternativeName: CLL-associated antigen KW-11 alternativeName: CTCL tumor antigen se1-1 alternativeName: Ran-binding protein 2-like 4 shortName: RanBP2L4 alternativeName: Renal carcinoma antigen NY-REN-53 |
| geneName | GCC2 KIAA0336 RANBP2L4 |
| identifier | Q8IWJ2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Coiled coil Cytoplasm Golgi apparatus Membrane Phosphoprotein Protein transport Proteomics identification Reference proteome Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GCC2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962533] ENSEMBL:ENSG00000135968 GCC2 [Homo sapiens] |
| secondaryIdentifier | GCC2_HUMAN A6H8X8 O15045 Q4ZG46 Q8TDH3 Q9H2G8 |
| sequenceLength | 1684 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:410847] UniProt:Q8IWJ2-1 GCC2 [Homo sapiens] [ReferenceIsoform:8975130] UniProt:Q8IWJ2-3 GCC2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6813880] GCC2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9713455] GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9713458] GCC2(1-1204)-ALK(1059-1620) fusion [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8IWJ2 GCC2 (91143)
