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Details on Person UniProt:Q96PP8 GBP5

Class:Id	ReferenceGeneProduct:91111
_chainChangeLog	chain:1-583 added on Fri February 6 2015;propeptide:584-586 added on Fri February 6 2015
_displayName	UniProt:Q96PP8 GBP5
_timestamp	2025-02-21 18:36:47
chain	chain:1-583 propeptide:584-586
checksum	95DDC02F0FB705D0
comment	FUNCTION Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:26996307, PubMed:31091448).FUNCTION Antigenic tumor-specific truncated splice form.CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)SUBUNIT Homodimer; homodimerizes upon GTP-binding, forming a close face-to-face dimer (PubMed:20180847, PubMed:21151871, PubMed:33876762). Heterodimer with other family members, including GBP1, GBP2, GBP3 and GBP4 (PubMed:21151871). May also form tetramers (dimer of dimers) in the presence of GTP (PubMed:20180847). Interacts with NLRP3, possibly in its tetrameric form, and promotes PYCARD/ASC polymerization (PubMed:22461501).SUBUNIT Homodimer; homodimerizes upon GTP-binding (PubMed:20180847). GDP-bound form remains homodimeric (PubMed:20180847).SUBUNIT Homodimer; homodimerizes upon GTP-binding (PubMed:20180847). GDP-bound is monomeric (PubMed:20180847).INTERACTION Expressed in peripheral blood monocytes (at protein level).INDUCTION By IFNG in endothelial cells and in LPS-primed macrophages.PTM Isoprenylation is required for proper subcellular location.SIMILARITY Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
description	recommendedName: Guanylate-binding protein 5 ecNumber evidence="7 9"3.6.5.- alternativeName: fullName evidence="14"GBP-TA antigen alternativeName: fullName evidence="15"GTP-binding protein 5 shortName evidence="15"GBP-5 alternativeName: fullName evidence="15"Guanine nucleotide-binding protein 5
geneName	GBP5 UNQ2427/PRO4987
identifier	Q96PP8
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Antimicrobial Cytoplasm Cytoplasmic vesicle Glycoprotein Golgi apparatus GPI-anchor GTP-binding Hydrolase Immunity Inflammatory response Innate immunity Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Proteomics identification Reference proteome
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	GBP5
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8962167] ENSEMBL:ENSG00000154451 GBP5 [Homo sapiens]
secondaryIdentifier	GBP5_HUMAN B2RCE1 Q86TM5
sequenceLength	586
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8969664] UniProt:Q96PP8-1 GBP5 [Homo sapiens] [ReferenceIsoform:8969665] UniProt:Q96PP8-2 GBP5 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:1031692] GBP5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9954196] GGC-C583-GBP5 [cytosol] [Homo sapiens]
(referenceSequence)	[GroupModifiedResidue:9954214] S-geranylgeranyl-L-cysteine (geranylgeranyl group) at 583
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No pathways have been reviewed or authored by UniProt:Q96PP8 GBP5 (91111)