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Details on Person (R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine

Class:Id	Reaction:909780
_displayName	(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine
_doRelease	TRUE
_timestamp	2025-12-16 18:01:17
authored	[InstanceEdit:909782] D'Eustachio, P, 2010-07-07
catalystActivity	[CatalystActivity:909768] (R)-3-amino-2-methylpropionate:pyruvate transaminase activity of AGXT2 tetramer [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:909782] D'Eustachio, P, 2010-07-07
crossReference	[DatabaseIdentifier:9976518] RHEA:18394
edited	[InstanceEdit:909782] D'Eustachio, P, 2010-07-07
inferredFrom	[Reaction:909775] (R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine [Rattus norvegicus]
input	[SimpleEntity:909779] 3AIB [mitochondrial matrix] [SimpleEntity:113557] PYR [mitochondrial matrix]
internalReviewed	[InstanceEdit:9977060] D'Eustachio, Peter, 2025-12-16
isChimeric	FALSE
literatureReference	[LiteratureReference:904862] Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production
modified	[InstanceEdit:909790] D'Eustachio, P, 2010-07-07 [InstanceEdit:941848] Garapati, P V, 2010-09-04 [InstanceEdit:996691] D'Eustachio, P, 2010-11-07 [InstanceEdit:1004537] D'Eustachio, P, 2010-11-09 [InstanceEdit:1080820] D'Eustachio, P, 2010-11-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9976516] D'Eustachio, Peter, 2025-12-11 [InstanceEdit:9977061] D'Eustachio, Peter, 2025-12-16 [InstanceEdit:9977063] D'Eustachio, Peter, 2025-12-16
name	(R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine
output	[SimpleEntity:379697] L-Ala [mitochondrial matrix] [SimpleEntity:9976511] 2-methyl-3-oxopropanoate [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:909755] Mitochondrial uptake of (R)-3-aminoisobutyric acid [Homo sapiens] [Reaction:73620] conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2010-12-14
reviewed	[InstanceEdit:1004534] Jassal, B, 2010-11-09 [InstanceEdit:9977064] D'Eustachio, Peter, 2025-12-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105679] R-HSA-909780.3
structureModified	[InstanceEdit:9976516] D'Eustachio, Peter, 2025-12-11
summation	[Summation:909778] Mitochondrial AGXT2 tetramer catalyzes the reaction of (R)-3...
(hasEvent)	[Pathway:73621] Pyrimidine catabolism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9984587] Update Tracker - [Reaction:909780] (R)-3-amino-2-methylpropanoate + pyruvate => 2-methyl-3-oxopropanoate + L-alanine - v96:[add_removeOutput]
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