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Details on Person Phosphorylation of INFAR1 by TYK2

Class:Id	Reaction:909730
_displayName	Phosphorylation of INFAR1 by TYK2
_doRelease	TRUE
_timestamp	2010-12-02 14:41:51
authored	[InstanceEdit:909728] Garapati, P V, 2010-07-07
catalystActivity	[CatalystActivity:909723] protein tyrosine kinase activity of IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:909728] Garapati, P V, 2010-07-07
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:909705] IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:909612] Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein [LiteratureReference:909614] Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase
modified	[InstanceEdit:913528] Garapati, P V, 2010-07-16 [InstanceEdit:933346] Garapati, P V, 2010-08-10 [InstanceEdit:933763] Garapati, P V, 2010-08-17 [InstanceEdit:941856] Garapati, P V, 2010-09-06 [InstanceEdit:994080] Garapati, P V, 2010-11-05 [InstanceEdit:998147] Garapati, P V, 2010-11-09 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of INFAR1 by TYK2
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:909704] IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:909729] Activation of JAK kinases [Homo sapiens] [Reaction:909724] Recruitment of IFNAR1 [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105913] R-HSA-909730.2
summation	[Summation:909666] TYK2 functions as part of a receptor complex to trigger intr...
(hasEvent)	[Pathway:909733] Interferon alpha/beta signaling [Homo sapiens]
(precedingEvent)	[Reaction:909719] Recruitment of STAT2 to p-IFNAR1 [Homo sapiens]
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No pathways have been reviewed or authored by Phosphorylation of INFAR1 by TYK2 (909730)