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Details on Person IFN alpha/beta binds to IFNAR2

Class:Id	Reaction:909720
_displayName	IFN alpha/beta binds to IFNAR2
_doRelease	TRUE
_timestamp	2020-07-20 10:49:16
authored	[InstanceEdit:909728] Garapati, P V, 2010-07-07
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:909728] Garapati, P V, 2010-07-07
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
input	[DefinedSet:909690] IFN alpha/beta (IFNA/B) [extracellular region] [Homo sapiens] [Complex:918193] IFNAR2:JAK1:STAT2 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:909627] The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding [LiteratureReference:909613] Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2 [LiteratureReference:909628] Ligand-induced assembling of the type I interferon receptor on supported lipid bilayers [LiteratureReference:909617] Lateral ligand-receptor interactions on membranes probed by simultaneous fluorescence-interference detection [LiteratureReference:909639] A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state [LiteratureReference:909583] The receptor of the type I interferon family [LiteratureReference:904798] Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling
modified	[InstanceEdit:918223] Garapati, P V, 2010-08-02 [InstanceEdit:933346] Garapati, P V, 2010-08-10 [InstanceEdit:933763] Garapati, P V, 2010-08-17 [InstanceEdit:941856] Garapati, P V, 2010-09-06 [InstanceEdit:994080] Garapati, P V, 2010-11-05 [InstanceEdit:998146] Garapati, P V, 2010-11-09 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9691239] Jassal, Bijay, 2020-06-10 [InstanceEdit:9696165] Jassal, Bijay, 2020-07-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	IFN alpha/beta binds to IFNAR2
output	[Complex:918195] IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] [Homo sapiens]
regulatedBy	[NegativeRegulation:9691242] Negative regulation by 'IFNAR2:JAK1:STAT2:JAK1,2 inhibitors [plasma membrane]' [PositiveRegulation:9696169] Positive regulation by 'IFNAR2:JAK1:STAT2:recombinant IFNB1 [plasma membrane]'
regulationReference	[RegulationReference:9691240] Negative regulation by 'IFNAR2:JAK1:STAT2:JAK1,2 inhibitors [plasma membrane]' Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050
releaseDate	2010-12-14
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104760] R-HSA-909720.3
summation	[Summation:909665] The ligand IFNalpha/beta (IFNA/B), interacts independently w...
(hasEvent)	[Pathway:909733] Interferon alpha/beta signaling [Homo sapiens]
(precedingEvent)	[Reaction:909724] Recruitment of IFNAR1 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776693] Update Tracker - [Reaction:909720] IFN alpha/beta binds to IFNAR2 - v74:[addRegulator]
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No pathways have been reviewed or authored by IFN alpha/beta binds to IFNAR2 (909720)