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Details on Person TYK2 functions as part of a receptor complex to trigger intr...

Class:IdSummation:909666
_displayNameTYK2 functions as part of a receptor complex to trigger intr...
_timestamp2010-11-08 18:45:46
created[InstanceEdit:909669] Garapati, P V, 2010-07-07
literatureReference[LiteratureReference:909614] Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase
[LiteratureReference:909612] Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein
modified[InstanceEdit:918144] Garapati, P V, 2010-08-02
[InstanceEdit:927714] Garapati, P V, 2010-08-06
[InstanceEdit:997283] Garapati, P V, 2010-11-08
textTYK2 functions as part of a receptor complex to trigger intracellular signaling in response to IFNA/B. TYK2 bound to IFNAR1 subunit is activated in response to IFNA/B treatment and this in turn phosphorylates two tyrosine residues Y466 and Y481 in the juxta-membrane region of IFNAR1.
(summation)[Reaction:909730] Phosphorylation of INFAR1 by TYK2 [Homo sapiens]
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