Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P18508 Gabrg2
| Class:Id | ReferenceGeneProduct:90910 |
|---|---|
| _chainChangeLog | signal peptide:1-38 added on Fri February 6 2015;chain:39-466 added on Fri February 6 2015 |
| _displayName | UniProt:P18508 Gabrg2 |
| _timestamp | 2024-08-09 19:01:26 |
| chain | signal peptide:1-38 chain:39-466 |
| checksum | 3C60B66E0D23072F |
| comment | FUNCTION Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2561970, PubMed:30044221). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:30044221). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:2561970, PubMed:30044221). Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (PubMed:9464994). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). Extrasynaptic gamma-2-containing receptors contribute to the tonic GABAergic inhibition (PubMed:9464994). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity).CATALYTIC ACTIVITY chloride(in) = chloride(out)ACTIVITY REGULATION Allosterically activated by benzodiazepines (By similarity). Activated by pentobarbital (PubMed:2561970). Inhibited by the antagonist bicuculline (PubMed:2561970). Inhibited by zinc ions (By similarity). Potentiated by histamine (By similarity).SUBUNIT Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) chains, each subunit exhibiting distinct physiological and pharmacological properties (PubMed:2561970, PubMed:30044221). Interacts with GABARAP (By similarity). Interacts with KIF21B (PubMed:25172774). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (PubMed:28279354). Interacts with LHFPL4 (By similarity). Interacts with SHISA7; interaction leads to the regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (By similarity).SUBCELLULAR LOCATION The gamma-2 subunits are present in Golgi synapses and on the extrasynaptic membranes (when associated with alpha-1/6 and beta-2/3 subunits), and in some of the mossy fiber to granule cell synapses (when associated with alpha-6 and beta-2/3 subunits). Present in GABAergic and glutamatergic synapses on granule cells.TISSUE SPECIFICITY Expressed in brain (at protein level). Expressed in lungs, in alveolar epithelium (PubMed:17003036).DOMAIN The extracellular domain contributes to synaptic contact formation.DOMAIN GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.PTM Palmitoylated by ZDHHC3/GODZ; required for the accumulation of GABA(A) receptors at the postsynaptic membrane of inhibitory GABAergic synapses.PTM Glycosylated.SIMILARITY Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily. |
| description | recommendedName: fullName evidence="2"Gamma-aminobutyric acid receptor subunit gamma-2 alternativeName: fullName evidence="2"GABA(A) receptor subunit gamma-2 shortName evidence="11"GABAAR subunit gamma-2 |
| geneName | Gabrg2 |
| identifier | P18508 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Cell projection Chloride Chloride channel Cytoplasmic vesicle Disulfide bond Glycoprotein Ion channel Ion transport Lipoprotein Membrane Palmitate Postsynaptic cell membrane Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9666080] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9688885] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Gabrg2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GBRG2_RAT |
| sequenceLength | 466 |
| species | [Species:48895] Rattus norvegicus |
| (referenceEntity) | [EntityWithAccessionedSequence:8856432] Gabrg2 [plasma membrane] [Rattus norvegicus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P18508 Gabrg2 (90910)
