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Details on Person UniProt:P63138 Gabrb2
| Class:Id | ReferenceGeneProduct:90893 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Fri February 6 2015;chain:26-474 added on Fri February 6 2015 |
| _displayName | UniProt:P63138 Gabrb2 |
| _timestamp | 2024-08-09 19:57:05 |
| chain | signal peptide:1-25 chain:26-474 |
| checksum | 8A815982EB70933E |
| comment | FUNCTION Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:1660002, PubMed:2548852). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:1660002). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). Extrasynaptic beta-2 receptors contribute to the tonic GABAergic inhibition (PubMed:9464994). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (PubMed:18281286).CATALYTIC ACTIVITY chloride(in) = chloride(out)ACTIVITY REGULATION Allosterically activated by benzodiazepines and the anesthetic etomidate (By similarity). Inhibited by the antagonist bicuculline (By similarity). Potentiated by histamine (PubMed:18281286).SUBUNIT Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) chains, each subunit exhibiting distinct physiological and pharmacological properties (PubMed:1660002, PubMed:18281286). Interacts with UBQLN1 (PubMed:11528422). May interact with KIF21B (PubMed:25172774). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (PubMed:28279354).SUBCELLULAR LOCATION The beta-2 subunits are present in Golgi synapses and on the extrasynaptic membranes (alpha-1/6-beta-2/3-gamma-2 receptors), and in some of the mossy fiber to granule cell synapses (alpha-6-beta-2/3-gamma-2 receptors). Present in GABAergic and glutamatergic synapses on granule cells (PubMed:9464994). The beta-2 subunit (alpha-6-beta-2/3-delta receptors) are found only on the extrasynaptic somatic and dendritic membranes (PubMed:9464994).TISSUE SPECIFICITY Expressed in brain (at protein level), in cerebellar granule cells. Expressed in lungs, in alveolar epithelium (PubMed:17003036).DOMAIN The extracellular domain contributes to synaptic contact formation.DOMAIN GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.PTM Glycosylated.SIMILARITY Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB2 sub-subfamily. |
| created | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 |
| description | recommendedName: fullName evidence="6"Gamma-aminobutyric acid receptor subunit beta-2 alternativeName: GABA(A) receptor subunit beta-2 shortName evidence="6"GABAAR subunit beta-2 |
| geneName | Gabrb2 Gabrb-2 |
| identifier | P63138 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Chloride Chloride channel Cytoplasmic vesicle Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Membrane Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9645038] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Gabrb2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GBRB2_RAT P15432 |
| sequenceLength | 474 |
| species | [Species:48895] Rattus norvegicus |
| (referenceEntity) | [EntityWithAccessionedSequence:8856421] Gabrb2 [plasma membrane] [Rattus norvegicus] |
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No pathways have been reviewed or authored by UniProt:P63138 Gabrb2 (90893)
