Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P35576 G6pc1
| Class:Id | ReferenceGeneProduct:90865 |
|---|---|
| _chainChangeLog | chain:1-357 added on Sat February 7 2015 |
| _displayName | UniProt:P35576 G6pc1 |
| _timestamp | 2023-11-03 18:29:22 |
| chain | chain:1-357 |
| checksum | 292163ACA7A44402 |
| comment | FUNCTION Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.CATALYTIC ACTIVITY D-glucose 6-phosphate + H2O = D-glucose + phosphatePATHWAY Carbohydrate biosynthesis; gluconeogenesis.SUBCELLULAR LOCATION Liver and kidney.DISRUPTION PHENOTYPE Deficient mice display hypoglycaemia, growth retardation, hepatomegaly, kidney enlargement, hyperlipidaemia, and hyperuricaemia.SIMILARITY Belongs to the glucose-6-phosphatase family. |
| description | recommendedName: Glucose-6-phosphatase catalytic subunit 1 ecNumber evidence="4"3.1.3.9 alternativeName: Glucose-6-phosphatase shortName: G-6-Pase shortName: G6Pase |
| geneName | G6pc1 G6pc G6pt |
| identifier | P35576 |
| isSequenceChanged | FALSE |
| keyword | Endoplasmic reticulum Gluconeogenesis Glycoprotein Hydrolase Membrane Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | G6pc1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | G6PC1_MOUSE Q91WV3 |
| sequenceLength | 357 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9623271] G6pc [endoplasmic reticulum membrane] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P35576 G6pc1 (90865)
