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Details on Person UniProt:Q9UNW8 GPR132
| Class:Id | ReferenceGeneProduct:90799 |
|---|---|
| _chainChangeLog | chain:1-380 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UNW8 GPR132 |
| _timestamp | 2024-11-03 19:36:33 |
| chain | chain:1-380 |
| checksum | 6DE63D17275ECD74 |
| comment | FUNCTION May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.SUBCELLULAR LOCATION Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity).ALTERNATIVE PRODUCTS Highly expressed in macrophages and hematopoietic tissues rich in lymphocytes, like spleen and thymus. Weakly expressed in heart and lung. In atherosclerotic plaques, expression is observed around the lipid core and at the shoulder region.INDUCTION By stress and DNA-damaging agents.MISCELLANEOUS More abundant than isoform 1 in leukocytes by approximately 3-fold.SIMILARITY Belongs to the G-protein coupled receptor 1 family.CAUTION Was originally thought to be a receptor for lysophosphatidylcholine (LPC) and sphingosylphosphorylcholine (SPC), However, this work has been retracted. |
| description | recommendedName: Probable G-protein coupled receptor 132 alternativeName: G2 accumulation protein |
| geneName | GPR132 G2A |
| identifier | Q9UNW8 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Membrane Proteomics identification Receptor Reference proteome Stress response Transducer Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GPR132 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003553] ENSEMBL:ENSG00000183484 GPR132 [Homo sapiens] |
| secondaryIdentifier | GP132_HUMAN A8K7X7 B4E144 Q9BSU2 |
| sequenceLength | 380 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:147659] UniProt:Q9UNW8-2 GPR132 [Homo sapiens] [ReferenceIsoform:415571] UniProt:Q9UNW8-1 GPR132 [Homo sapiens] [ReferenceIsoform:8972413] UniProt:Q9UNW8-3 GPR132 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:444699] GPR132 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9UNW8 GPR132 (90799)
